All seminars take place on Mondays from 4:00 pm - 5:00 pm in LEEP2 2420, unless otherwise specified.
3:00pm in LEEP2 1420
Speaker: Sunggook Park, PhD
Professor, Mechanical & Industrial Engineering Department and Center for BioModular Multiscale Systems (CBM2)
Louisiana State University
Nanomolding: Towards Discoveries and Production
Nanomolding is a technology for fabricating nanostructured surfaces that make this technology highly accessible to the research and commercial sectors. The ability to create topological and chemical patterns at micro- and nanometer scale, down to sub-10 nm, has made nanomolding suitable for various research areas intersecting biological and physical sciences in which some of the most exciting, novel, and promising discoveries are being made. This is because these size scales are extremely relevant to both biological and physical sciences, resulting in a succession of research advances that combine techniques relevant to the two fields. Also, the capability of large area and high throughput patterning has made nanomolding as one of few technologies with the potential to transition from proof-of-concept devices to commercializable products. Despite such promises, there are still many engineering challenges to overcome in order to realize nanomolding as a reliable manufacturing tool for both new discoveries and production. The challenges include development of high quality nanoscale molding tools, improvement of molding/demolding processes, as well as development of 2D and 3D integration strategies of other structural and electrical components.
This talk will consist of two parts. The first part will address how to overcome some of the engineering challenges mentioned above. Understanding of fundamentals to the demolding process is essential to the development of improved molding tools and processes. Production of 3D structures via molding and integration of pre-grown nanowires into molded nanofluidic structures will be discussed. In the second part, current efforts to use molded nanostructures in several applications in my laboratory will be presented.
Dr. Sunggook Park is currently the L.R. Daniel Professor of Mechanical Engineering at Louisiana State University (LSU-ME). He also serves as the director of the ME graduate program in the department. He received his B.S. and M.S. in 1996 and 1998, respectively, in the department of Chemical Engineering, Yonsei University, Seoul, Korea. He received his Ph.D. of physics from Technical University Chemnitz, Germany in 2002. The research topic for his Ph.D. dissertation was the electronic properties of surfaces and interfaces of organic semiconductors. Then, he moved to the Laboratory for Micro- and Nanofabrication at the Paul Scherrer Institute as a postdoctoral researcher from 2002-2004 where he gained expertise in nanomolding and nanofabrication. His current research interests at LSU focuses on fundamentals of nanomolding, such as thermal and mechanical behaviors, applications of molded structures in BioMEMS/NEMS, and 3-D patterning. He is a recipient of the NSF Young Faculty Development CAREER Award in 2007. He is currently a co-PI for the NIH P41 Center for BioModular Multi-Scale Systems for Precision Medicine and is leading the center efforts at LSU
4:00pm in LEEP2 2420
Speaker: Mei He, PhD
Assistant Professor, Department of Chemical Engineering and Petroleum, Department of Chemistry, affiliated with Bioengineering program
University of Kansas
Bio-inspired Micro/Nano-Manufacturing for Precision Therapeutics
Understanding the complexity and high adaptability of human immunity allows us to take advantages of nature's insights for overcoming current challenges imposed on therapeutic manufacturing systems. Such immunity intelligence harnesses the structure, function, and information in one ecosystem for self-learned, adaptive problem solving. Inspired by the human immunity which manipulates immune cells and organs to produce therapeutic solutions, we are interested to develop an intelligent living tissue foundry for producing nano-sized extracellular vesicles. The extracellular vesicles have been well documented as the therapeutic biomaterials for modulating immune-responses, disease targeting, and drug delivery via transferring groups of biomolecules. However, the immune-modulation mechanism and associated engineering approaches are still lacking. This presentation introduces cutting-edge 3D microfluidic technology and bioprinting for studying live cell manufactured extracellular vesicles and exosomes, which will have an important implication on the cancer immunotherapy.
Speaker: BIOE Graduate Students - Nate Oborny, Alyssa Rollando, Eileen Cadel, Renae Waters, Ember Krech
Internships: How to Maximize your Experience
This will be a panel discussion on various topics surrounding internships and will engage the audience with questions and feedback.
September 25th: RESCHEDULED
Speaker: Jocelyn Isley, MS, CIP
Interim IRB Administrator, Human Research Protection Program
The University of Kansas
IRBs and Human Research Regulations
Institutional Review Boards (IRBs) are a requirement for any institution receiving federal funding for human subject research—this includes the University of Kansas. Investigators conducting human research are required to have their project reviewed by the IRB before any research procedures take place. This presentation will provide information on the history and mission of IRBs, when IRB approval is required, basic information on the Belmont Report and human research regulations, and tips and suggestions when submitting your human research study to the KU-Lawrence IRB.
Speaker: Eduardo Rosa-Molinar, PhD
Director of Microscopy and Analytical Imaging Core Resource Laboratory, University of Kansas
Professor of Pharmacology and Toxicology and Neuroscience Graduate Program, University of Kansas
Agnotology of Synapses
However, because of agnotology, doubt or ignorance surrounding a subject, chemical synapses are generally studied in more detail than are electrical or mixed synapses. As a result, we have only a simplistic picture of the central nervous system. Thus, the focus of this presentation is how imaging studies and analyses of the multiple nanoscale cellular components of synapses is overcoming agnotology regarding synapses and is beginning to elucidate their role in influencing neuronal shape and function.
Research supported by NIH SBIR grants 1R43 MH106245-01 (from NIMH), 1R43 GM115042-01 (from NIGMS), 1R43EB015845-01 (from NIBIB), 5R25GM078441-10 (from NIGMS), and by HRD-1137725 (from NSF).