Malcolm L. Snead D.D.D, PH.D.
University of Southern California - Laboratory Developmental BiologyTitles
-Chair, Division of Biomedical Sciences
-Herman Ostrow School of Dentistry
-University of Southern California
Associated Tracks
-Biomedical Sciences with special training in Pathology and Biomaterials
Research Interests
-Amplifying cell signals for potentially lower cost stem cell interventions
Education
UNIVERSITY EDUCATION
Secondary Doctoral Degree &
Postdoctoral Education:
1981-1982 University of Southern California
Laboratory Developmental Biology
University Park MC-0191
Los Angeles, California, 90089-0191
Mentor: Dr. Harold C. Slavkin
1982 Baylor College of Medicine
Howard Hughes Medical Institute
Houston, Texas
Mentor: Dr. Savio L.C. Woo
1977-1981 The University of Chicago
Department of Pathology
Chicago, Illinois
Doctor of Philosophy, 1981
Mentor: Dr. Stephen A. Schwartz
1977-1979 The University of Chicago
The Zoller Dental Clinic
Chicago, Illinois
Oral Pathology: Board Eligible
Chief Resident 1979
Certificate 1979
Board Eligible
Mentors: Dr. Robert Goepp and Dr. Reza Mostofi
Primary Doctoral Degree:
1973-1977 Loyola University, School of Dentistry
Chicago, Illinois
Doctor of Dental Surgery, 1977
Undergraduate Education:
1969-1973 Saint Mary's College of California
Moraga, California
Bachelor of Science, 1973
Teaching
1995 to present Creation of Problem Based Learning Curriculum
Pilot Curriculum-USC Dental School
1995 to present Lecturer
Biochemistry and Molecular Biology
School of Dentistry
The University of Southern California
1996 to present Co-Director and Co-Developer (with Dr. S. Tahara)
Ethics in Research
Graduate School
The University of Southern California
1995 to present Director and Developer
Biomineralization
Graduate School
The University of Southern California
1994 to present Co-Director
Infectious Diseases
School of Dentistry
The University of Southern California
1992 to present Participant
Molecular Genetics of Embryonic Development
Biochemistry and Molecular Biology
The University of Southern California
School of Medicine
1992 to present Course Co-Director and Co-Developer
(With Charles Shuler)
Molecular Oral Pathology
Craniofacial Biology Program
The University of Southern California
School of Dentistry
1992 Course Director
Pathology
Second Year Undergraduate Students
The University of Southern California
School of Dentistry
1990 to present Course Director and Developer
Grand Rounds (Faculty Re-Development)
University of Southern California
School of Dentistry
1990 to present Course Co-Director and Co-Developer (with Dr. H.C. Slavkin)
Molecular Developmental Biology
Department of Biology
3 contact hours/week
The University of Southern California
1985-1990 Course Director and Developer
Advanced Oral Histology
2 contact hours/week
The University of Southern California
School of Dentistry
1984-1985 Participant
Human Development and Genetics,
6 contact hours
The University of Southern California
School of Dentistry
1984-1985 Participant
Pathophysiology of Human Diseases
MALCOLM L. SNEAD DDS PHD 12
4 contact hours
The University of Southern California
School of Dentistry
1979-1982 Participant
Oral Pathology
6 contact hours/week
Loyola University
School of Dentistry
1981-1983- Course Director and Developer
Current Topics in Molecular Biology
4 contact hours/week
Loyola University
School of Dentistry
1979-1980 Participant
Cell Pathophysiology
12 contact hours/week
The University of Chicago
Pritzker School of Medicine
CONTINUING MEDICAL EDUCATION
2010 Academy of Microscope Enhanced Dentistry
2009 American Association of Oral and Maxillofacial Surgeons
1999-2002 University of Southern California
Training Facilitators in Problem Based Learning
1999 University of Washington
Engineered Biomaterials Program
1999 University of Chicago
Department of Surgery
1998 University of Oslo, Oslo, Norway
European Dental Enamel Symposia
1997 University of Michigan, Ann Arbor Oral Health Science Seminars
1996 University of California, Los Angeles Molecular Biology Series
1995 University of Maryland, Baltimore College of Dental Surgery
1995 State University of New York, Buffalo Department of Oral Biology
1995 American Association for Dental Research Transgenic Animal Models in Dental Research
1993 New Jersey University of Medicine and Dentistry School of Dentistry
1991 Department of Pathology Children's Hospital
1990 Department of Veterans Affairs Jerry L. Pettis Memorial Hospital
1990 The Forsyth Dental Center
1989 The University of Texas Health Science Center The University of Texas Dental Branch, Houston
1989 American Academy of Oral Pathology Methods in Molecular Biology: In situ Hybridization
Selected Publications
2015
A Proline-Rich Peptide Mimic Effects of EMD in Rat Oral Mucosal Incisional Wound Healing.,
Villa O, Wohlfahrt JC, Mdla I, Petzold C, Reseland JE, Snead ML, Lyngstadaas SP. J
Periodontol. 2015 Aug 7:1-18. [Epub ahead of print], PMID:26252748
Store-operated Ca2+ Entry Modulates the Expression of Enamel Genes., Nurbaeva MK,
Eckstein M, Snead ML, Feske S, Lacruz RS, J Dent Res. 2015 Jul 31. pii:
0022034515598144. [Epub ahead of print], PMID:26232387
Hypoxia increases the expression of enamel genes and cytokines in an ameloblast-derived
cell line, Sidaly R, Landin MA, Suo Z, Snead ML, Lyngstadaas SP, Reseland JE. Eur J
Oral Sci. 2015 Jul 20. doi: 10.1111/eos.12201. [Epub ahead of print], PMID:26193448
Regulation of the Stem Cell-Host Immune System Interplay Using Hydrogel Coencapsulation
System with an Anti-Inflammatory Drug, Moshaverinia A, Chen C, Xu X, Ansari S,
Zadeh HH, Schricker SR, Paine ML, Moradian-Oldak J, Khademhosseini A, Snead ML,
Shi S., Adv Funct Mater. 2015 Apr 15;25(15):2296-2307. PMID:26120294
Protein Interaction between Ameloblastin and Proteasome Subunit α Type 3 Can Facilitate
Redistribution of Ameloblastin Domains within Forming Enamel, Geng S, White SN,
Paine ML, Snead ML., J Biol Chem. 2015 Aug 21;290(34):20661-73. doi:
10.1074/jbc.M115.640185. Epub 2015 Jun 12., PMID:26070558
MALCOLM L. SNEAD DDS PHD 15
Chimeric Peptides as Implant Functionalization Agents for Titanium Alloy Implants with
Antimicrobial Properties, DT Yucesoy, M Hnilova, K Boone, PM Arnold, ML Snead and
C Tamerler, April 2015, JOM, 67, 4, pp 754-766
Biomineralization of a Self-assembled, Soft-Matrix Precursor: Enamel, Malcolm L. Snead,
April 2015, JOM, 67, 4, pp 788-795
Bio-inspired hard-to-soft interface for implant integration to bone. Zhou Y, Snead ML,
Tamerler C. Nanomedicine. 2014 Nov 22. pii: S1549-9634(14)00554-1. doi:
10.1016/j.nano.2014.10.003. PMID: 25461292
High-fluoride promoted phagocytosis-induced apoptosis in a matured ameloblast-like cell line.
Yang T, Zhang Y, Zheng D, Hao Y, Snead ML, Duan X. Arch Oral Biol. 2015
Jan;60(1):84-90. doi: 10.1016/j.archoralbio.2014.09.001. Epub 2014 Sep 17. PMID:
25260155
2014
Comparison of two mouse ameloblast-like cell lines for enamel-specific gene expression.
Sarkar J, Simanian EJ, Tuggy SY, Bartlett JD, Snead ML, Sugiyama T, Paine ML. Front
Physiol. 2014 Jul 25;5:277. doi: 10.3389/fphys.2014.00277. eCollection 2014.
PMID:25120490
Concise review: mesenchymal stromal cells used for periodontal regeneration: a systematic
review. Monsarrat P, Vergnes JN, Nabet C, Sixou M, Snead ML, Planat-Bénard V,
Casteilla L, Kémoun P. Stem Cells Transl Med. 2014 Jun;3(6):768-74. doi:
10.5966/sctm.2013-0183. Epub 2014 Apr 17. Review. PMID: 24744392
Application of stem cells derived from the periodontal ligament or gingival tissue sources for
tendon tissue regeneration. Moshaverinia A, Xu X, Chen C, Ansari S, Zadeh HH, Snead
ML, Shi S. Biomaterials. 2014 Mar;35(9):2642-50. doi:
10.1016/j.biomaterials.2013.12.053. Epub 2014 Jan 4. PMID: 24397989
A model for the molecular underpinnings of tooth defects in Axenfeld-Rieger syndrome. Li X,
Venugopalan SR, Cao H, Pinho FO, Paine ML, Snead ML, Semina EV, Amendt BA.
Hum Mol Genet. 2014 Jan 1;23(1):194-208. doi: 10.1093/hmg/ddt411. Epub 2013 Aug
23. PMID: 23975681
2013
Dental mesenchymal stem cells encapsulated in an alginate hydrogel co-delivery
microencapsulation system for cartilage regeneration. Moshaverinia A, Xu X,
Chen C, Akiyama K, Snead ML, Shi S. Acta Biomater. 2013 Dec;9(12):9343-50. doi:
10.1016/j.actbio.2013.07.023. Epub 2013 Jul 26. PMID: 23891740
Co-encapsulation of anti-BMP2 monoclonal antibody and mesenchymal stem cells in
alginate microspheres for bone tissue engineering. Moshaverinia A, Ansari S,
Chen C, Xu X, Akiyama K, Snead ML, Zadeh HH, Shi S. Biomaterials. 2013
Sep;34(28):6572-9. doi: 10.1016/j.biomaterials.2013.05.048. Epub 2013 Jun 14.
PMID: 23773817
MALCOLM L. SNEAD DDS PHD 16
Role of the NH2 -terminal fragment of dentin sialophosphoprotein in dentinogenesis.
Gibson MP, Liu Q, Zhu Q, Lu Y, Jani P, Wang X, Liu Y, Paine ML, Snead ML, Feng
JQ, Qin C. Eur J Oral Sci. 2013 Apr;121(2):76-85. doi: 10.1111/eos.12020. Epub
2013 Feb 7. PMID: 23489896
The role of bioactive nanofibers in enamel regeneration mediated through integrin signals
acting upon C/EBPα and c-Jun. Huang Z, Newcomb CJ, Zhou Y, Lei YP, Bringas P Jr,
Stupp SI, Snead ML. Biomaterials. 2013 Feb 8. doi:pii: S0142-9612(13)00082-3.
10.1016/j.biomaterials.2013.01.054. PMID:23398885
Biological response on a titanium implant-grade surface functionalized with modular peptides.
Yazici H, Fong H, Wilson B, Oren EE, Amos FA, Zhang H, Evans JS, Snead ML,
Sarikaya M, Tamerler C. Acta Biomater. 2013 Feb;9(2):5341-52. PMID: 23159566
2012
Biomimetic mineralization: the role of nanoscale architecture in supramolecular templating of
biomimetic hydroxyapatite mineralization (small 14/2012). Newcomb CJ, Bitton R,
Velichko YS, Snead ML, Stupp SI. Small. 2012 Jul 23;8(14):2194.PMID:22791330
Cementomimetics-constructing a cementum-like biomineralized microlayer via amelogeninderived
peptides. Gungormus M, Oren EE, Horst JA, Fong H, Hnilova M, Somerman
MJ, Snead ML, Samudrala R, Tamerler C, Sarikaya M. Int J Oral Sci. 2012 Jun;4(2):69-
77. PMID:22743342
Characterization of dental epithelial stem cells from the mouse ncisor with 2D and 3D
Platforms. Chavez MG, Yu W, Biehs B, Harada H, Snead ML, Klein OD. Tissue Eng
Part C Methods. 2012 PMID: 22742471
The circadian clock modulates enamel development. Lacruz RS, Hacia JG, Bromage TG,
Boyde A, Lei Y, Xu Y, Miller JD, Paine ML, Snead ML. J Biol Rhythms. 2012
Jun;27(3):237-45. PMID:22653892
The role of nanoscale architecture in supramolecular templating of biomimetic hydroxyapatite
mineralization. Newcomb CJ, Bitton R, Velichko YS, Snead ML, Stupp SI. Small. 2012
Jul 23;8(14):2195-202. PMID:22570174
Targeted overexpression of amelotin disrupts the microstructure of dental enamel.
Lacruz RS, Nakayama Y, Holcroft J, Nguyen V, Somogyi-Ganss E, Snead ML, White SN,
Paine ML, Ganss B. PLoS One. 2012;7(4). PMID:22539960
2011
Ameloblastin upstream region contains structural elements regulating transcriptional activity
in a stromal cell line derived from bone marrow. Tamburstuen MV, Snead ML, Reseland
JE, Paine ML, Lyngstadaas SP. Eur J Oral Sci. 2011 Dec;119 Suppl 1:286-92.
PMID:22243258
MALCOLM L. SNEAD DDS PHD 17
Epithelial-specific knockout of the Rac1 gene leads to enamel defects. Huang Z, Kim J,
Lacruz RS, Bringas P Jr, Glogauer M, Bromage TG, Kaartinen VM, Snead ML. Eur J
Oral Sci. 2011 Dec;119 Suppl 1:168-76. PMID:22243243
Identification of novel candidate genes involved in mineralization of dental enamel by
genome-wide transcript profiling. Lacruz RS, Smith CE, Bringasjr P, Chen YB, Smith
SM, Snead ML, Kurtz I, Hacia JG, Hubbard MJ, Paine ML. J Cell Physiol. PMID:
21809343
The role of cell surface markers and enamel matrix derivatives on human periodontal
ligament mesenchymal progenitor responses in vitro. Kémoun P, Gronthos S, Snead
ML, Rue J, Courtois B, Vaysse F, Salles JP, Brunel G. Biomaterials. 2011 32(30):7375-
88. PMID: 21784516
The influence of Leucine-rich amelogenin peptide on MSC fate by inducing Wnt10b
expression. Wen X, Cawthorn WP, MacDougald OA, Stupp SI, Snead ML, Zhou Y.
Biomaterials. 2011 32(27):6478-86. PMID: 21663957
Folding, assembly, and aggregation of recombinant murine amelogenins with T21I and P41T
point mutations. Bromley KM, Lakshminarayanan R, Lei YP, Snead ML, Moradian-
Oldak J. Cells Tissues Organs. 2011;194(2-4):284-90. PMID: 21540557
Structural analysis of a repetitive protein sequence motif in strepsirrhine primate amelogenin.
Lacruz RS, Lakshminarayanan R, Bromley KM, Hacia JG, Bromage TG, Snead ML,
Moradian-Oldak J, Paine ML. PLoS One. 2011 Mar 18;6(3):e18028. PMID: 21437261
A simplified genetic design for mammalian enamel. Snead ML, Zhu DH, Lei Y, Luo W,
Bringas PO Jr, Sucov HM, Rauth RJ, Paine ML, White SN. Biomaterials. 2011
Apr;32(12):3151-7. Epub 2011 Feb 5. PMID: 21295848
PERP regulates enamel formation via effects on cell-cell adhesion and gene expression.
Jheon AH, Mostowfi P, Snead ML, Ihrie RA, Sone E, Pramparo T, Attardi LD, Klein OD.
J Cell Sci. 2011 Mar 1;124(Pt 5):745-54. PMID: 21285247
Ameloblastin expression and putative autoregulation in mesenchymal cells suggest a role in
early bone formation and repair. Tamburstuen MV, Reseland JE, Spahr A, Brookes SJ,
Kvalheim G, Slaby I, Snead ML, Lyngstadaas SP. Bone. 2011 Feb 1;48(2):406-13.
PMID:20854943
2010
Serotonin and fluoxetine receptors are expressed in enamel organs and LS8 cells and
modulate gene expression in LS8 cells. Riksen EA, Stunes AK, Kalvik A, Gustafsson BI,
Snead ML, Syversen U, Lyngstadaas SP, Reseland JE. Eur J Oral Sci. 2010
Dec;118(6):566-73. doi: 10.1111/j.1600-0722.2010.00778.x. PMID: 21083617
Perturbed amelogenin secondary structure leads to uncontrolled aggregation in amelogenesis
imperfecta mutant proteins. Lakshminarayanan R, Bromley KM, Lei YP, Snead ML,
Moradian-Oldak J. J Biol Chem. 2010 Dec 24;285(52):40593-603. PMID: 20929860
MALCOLM L. SNEAD DDS PHD 18
Biological synthesis of tooth enamel instructed by an artificial matrix. Huang Z, Newcomb CJ,
Bringas P Jr, Stupp SI, Snead ML. Biomaterials. 2010 Dec;31(35):9202-11. PMID:
20869764
Full length amelogenin binds to cell surface LAMP-1 on tooth root/periodontium associated
cells. Zhang H, Tompkins K, Garrigues J, Snead ML, Gibson CW, Somerman MJ. Arch
Oral Biol. 2010 55(6):417-25. PMID: 20382373
A solution NMR investigation into the murine amelogenin splice-variant LRAP (Leucine-Rich
Amelogenin Protein). Buchko GW, Tarasevich BJ, Roberts J, Snead ML, Shaw WJ.
Biochim Biophys Acta. 2010;1804(9):1768-74. PMID: 20304108
2009
Dental enamel: genes define biomechanics. Rauth RJ, Potter KS, Ngan AY, Saad DM, Mehr
R, Luong VQ, Schuetter VL, Miklus VG, Chang P, Paine ML, Lacruz RS, Snead ML,
White SN. J Calif Dent Assoc. 2009;37(12):863-8. PMID: 20066874
Science is the fuel for the engine of technology and clinical practice. Snead ML, Slavkin HC.
J Am Dent Assoc. 2009;140 Suppl 1:17S-24S.PMID: 19723927
Enamel matrix proteins; old molecules for new applications. Lyngstadaas SP, Wohlfahrt JC,
Brookes SJ, Paine ML, Snead ML, Reseland JE. Orthod Craniofac Res.
2009;12(3):243-53. PMID: 19627527
Leucine-rich amelogenin peptide induces osteogenesis by activation of the Wnt pathway.
Warotayanont R, Frenkel B, Snead ML, Zhou Y. Biochem Biophys Res Commun.
2009;387(3):558-63. PMID:
2008
Wen, X., Zou, Y.M., Luo, W., Goldberg, M., Moats, R., Conti, P.S., Snead, M.L., and Paine,
M.L. Biglycan overexpression on tooth enamel formation in transgenic mice. The
Anatomical Record, 291, 1246-1253, 2008.
Paine, M.L., Snead, M.L., Wang, H.J., Abuladze, N., Pushkin, A., Liu, W., Kao, L.Y., Wall,
S.M., Kim, Y.H., and Kurtz, I. Role of NBCe1 and AE2 in secretory ameloblasts. Journal
of Dental Research, 87, 391-395, 2008.
2007
Zou, Y.M., Wang, H.J., Shapiro, J.L., Okamoto, C.T., Brookes, S.J., Lyngstadaas, S.P.,
Snead, M.L., and Paine, M.L. Determination of protein regions responsible for
interactions of amelogenin with CD63 and LAMP1. Biochemical Journal, 408, 347-354,
2007.
Tarasevich, B.J., Howard, C.J., Larson, J.L., Snead, M.L., Simmer, J.P., Paine, M., and
Shaw, W.J. The nucleation and growth of calcium phosphate by amelogenin. Journal of
Crystal Growth, 304, 407-415, 2007. (doi:10.1016/j.crysgro.2007.02.035)
MALCOLM L. SNEAD DDS PHD 19
White, S.N., Paine, M.L., Ngan, A.Y.W., Miklus, V.G., Luo, W., Wang, H.J. and Snead, M.L.,
Ectopic expression of Dsp during amelogenesis hardens bulk enamel. Journal of
Biological Chemistry, 282, 5340-5345, 2007.
Shapiro, J.L., Wen, X., Okamoto, C.T., Wang, H.J., Lyngstadaas, S.P., Goldberg, M., Snead,
M.L. and Paine, M.L. Cellular uptake of amelogenin, and its localization to CD63, and
Lamp1-positive vesicles. Cellular and Molecular Life Sciences, 64, 244-256, 2007.
2006
Snead, M.L., Zhu, D.H., Lei, Y.P., White, S.N., Snead, C.M., Luo, W., and Paine, M.L. Protein
self-assembly creates a nanoscale device for biomineralization. Materials Science and
Engineering: C, 26(8), 1296-1300, 2006.
Zhu, D.H., Paine, M.L., Luo, W., Bringas, P. Jr., and Snead, M.L. Altering biomineralization
by protein design. Journal of Biological Chemistry, 281, 21173-21182, 2006.
Wang, H.J., Tannukit, S., Shapiro, J.L., Snead, M.L. and Paine, M.L. Using the yeast twohybrid
assay to discover protein partners for the leucine-rich amelogenin peptide (LRAP)
and for tuftelin-interacting protein 11 (TFIP11). European Journal of Oral Sciences,
114(Suppl. 1), 276-279, 2006.
Swanson, E.C., Fong, H.K., Foster, B.L., Paine, M.L., Gibson, C.W., Snead, M.L., and
Somerman, M.J. Amelogenins regulate expression of genes associated with
cementoblasts in vitro. European Journal of Oral Sciences, 114(Suppl. 1), 239-243,
2006.
Bartlett JD, Ganss B, Goldberg M, Moradian-Oldak J, Paine ML, Snead ML, Wen X, White
SN and Zhou YL. (2006) Protein-protein interactions of the developing enamel matrix.
Curr Top Dev Biol. 74:57-115.
Zhu D, Paine ML, Luo W, Bringas P Jr. and Snead ML. (2006) Altering biomineralization by
protein design. J Biol Chem. 281(30):21173-82.
Bartold PM, Xiao Y, Lyngstaadas SP, Paine ML and Snead ML. (2006) Principles and
applications of cell delivery systems for periodontal regeneration. Periodontol 2000.
41:123-35.
Wang HJ, Tannukit S, Wen X, Shapiro JL, Snead ML and Paine ML. (2006) Using the yeast
two-hybrid assay to discover protein partners for the leucine-rich amelogenin peptide
and for tuftelin-interacting protein-11. Eur J Oral Sci. 114 Suppl 1:276-9.
Swanson EC, Fong HK, Foster BL, Paine ML, Gibson CW, Snead ML and Somerman MJ.
(2006) Amelogenins regulate expression of genes associated with cementoblasts in
vitro. Eur J Oral Sci. 114 Suppl 1:239-43.
Xu Y, Zhou YL, Ann DK, MacDougald OA, Shum L and Snead ML. (2006). Transcription
factor sumoylation and factor YY1 serve to modulate mouse amelogenin gene
expression. Eur J Oral Sci. 114 Suppl 1:169-77.
MALCOLM L. SNEAD DDS PHD 20
Xu Y, Zhou YL, Luo W, Zhu QS, Levy D, MacDougald OA, Snead ML. (2006) NF-Y and
CCAAT/enhancer-binding protein alpha synergistically activate the mouse amelogenin
gene. J Biol Chem. 281 (23):16090-16098.
2005
Paine ML and Snead ML. (2005) Tooth developmental biology: disruptions to enamel-matrix
assembly and its impact on biomineralization. Orthod Craniofac Res. 8(4):239-51.
White SN, Miklus VG, Chang PP, Caputo AA, Fong H, Sarikaya M, Luo W, Paine ML, Snead
ML. (2005) Controlled failure mechanisms toughen the dentino-enamel junction zone. J
Prosthet Dent. 94(4):330-5.
Plikus MV, Zeichner-David M, Mayer JA, Reyna J, Bringas P, Thewissen JG, Snead ML,
Chai Y, Chuong CM. (2005) Morphoregulation of teeth: modulating the number, size,
shape and differentiation by tuning Bmp activity. Evol Dev. 7(5):440-57.
Paine ML, Luo W, Wang HJ, Bringas P Jr, Ngan AY, Miklus VG, Zhu DH, MacDougall M,
White SN, Snead ML. (2005) Dentin sialoprotein and dentin phosphoprotein
overexpression during amelogenesis. J Biol Chem. 280(36):31991-8.
Wang H, Tannukit S, Zhu D, Snead ML, Paine ML. (2005) Enamel matrix protein
interactions. J Bone Miner Res. 20(6):1032-40.
Wen X, Lei YP, Zhou YL, Okamoto CT, Snead ML, Paine ML. Structural organization and
cellular localization of tuftelin-interacting protein 11 (TFIP11). (2005) Cell Mol Life Sci.
62(9):1038-46.
Kubota K, Lee DH, Tsuchiya M, Young CS, Everett ET, Martinez-Mier EA, Snead ML,
Nguyen L, Urano F, Bartlett JD. (2005) Fluoride induces endoplasmic reticulum stress
in ameloblasts responsible for dental enamel formation. J Biol Chem. 280(24):23194-
202.
2004
Luo W, Wen X, Wang HJ, MacDougall M, Snead ML, Paine ML. (2004). In vivo
overexpression of tuftelin in the enamel organic matrix. Cells Tissues Organs.
177(4):212-20.
Shaw WJ, Campbell AA, Paine ML, Snead ML. (2004). The COOH Terminus of the
Amelogenin, LRAP, Is Oriented Next to the Hydroxyapatite Surface. J Biol Chem.
279(39):40263-6
Paine ML, Zhu DH, Luo W, Snead ML. (2004). Overexpression of TRAP in the Enamel Matrix
Does Not Alter the Enamel Structural Hierarchy. Cells Tissues Organs, 176:7-16.
2003
MALCOLM L. SNEAD DDS PHD 21
Fong H, White SN, Paine ML, Luo W, Snead ML, Sarikaya M. (2003). Enamel structure
properties controlled by engineered proteins in transgenic mice. J Bone Miner Res.
18(11):2052-9
Snead ML. (2003). Amelogenin protein exhibits a modular design: implications for form and
function. Connect Tissue Res. 2003;44 Suppl 1:47-51.
Wu LY, Li M, Hinton DR, Guo L, Jiang S, Wang JT, Zeng A, Xie JB, Snead ML, Shuler C,
Maxson RE Jr, Liu YH. (2003). Microphthalmia Resulting from Msx2-Induced Apoptosis
in the Optic Vesicle. Invest Ophthalmol Vis Sci 44, 2404-2412.
Paine ML., Wang HJ and Snead ML. (2003). Amelogenin Self-Assembly and the Role of the
Proline Located within the Carboxyl-Teleopeptide. Connective Tissue Research,
44(Suppl. 1): 52-57.
Paine ML, Luo W, Zhu DH, Bringas P Jr, Snead ML. (2003). Functional domains for
amelogenin revealed by compound genetic defects. J Bone Miner Res 18(3):466-72
Paine ML, Wang HJ, Luo W, Krebsbach PH, Snead ML. (2003). A transgenic animal model
resembling amelogenesis imperfecta related to ameloblastin over-expression. J Biol
Chem 278:19447-52
2002
Dunglas, C., Septier, D., Paine, M.L., Zhu, D.H., Snead, M.L., and Goldberg, M. (2002).
Ultrastructure of forming enamel in mouse bearing a transgene that disrupts the
amelogenin self-assembly domains. Calcif Tissue Int ; 71(2):155-66
Jitpukdeebodintra, S., Chai, Y., and Snead ML. (2002). Developmental patterning of the
circumvallate papilla. Int. J. Dev. Biol. 46, 755-763.
Paine ML, Lei YP, Dickerson K, Snead ML. (2002). Altered Amelogenin Self-assembly Based
on Mutations Observed in Human X-linked Amelogenesis Imperfecta (AIH1). J Biol
Chem 277(19):17112-6
2001
Green PD, Hjalt TA, Kirk DE, Sutherland LB, Thomas BL, Sharpe PT, Snead ML, Murray JC,
Russo AF, Amendt BA. (2001) Antagonistic regulation of Dlx2 expression by PITX2 and
Msx2: implications for tooth development. Gene Expr. 9(6):265-281.
Paine ML, White SN, Luo W, Fong H, Sarikaya M, Snead ML. (2001) Regulated gene
expression dictates enamel structure and tooth function. Matrix Biol. 20(5-6):273-292.
White SN, Luo W, Paine ML, Fong H, Sarikaya M, Snead ML. (2001) Biological organization
of hydroxyapatite crystallites into a fibrous continuum toughens and controls anisotropy
in human enamel. J Dent Res. 80(1):321-326.
2000
MALCOLM L. SNEAD DDS PHD 22
Liu YH, Snead ML, Maxson RE. (2000) Transgenic mouse models of craniofacial disorders.
Methods Molecular Biology. 137:499-512.
Paine ML, Zhu DH, Luo W, Bringas P Jr., Goldberg M, White SN, Lei YP, Sarikaya M, Fong
HK, Snead ML. (2000) Enamel biomineralization defects result from alterations to
amelogenin self-assembly. J Structural Biology. 132:191-200.
White, S.N., Paine, M.L., Luo, W., Sarikaya, M., Fong, H., Yu, Z., Li, Z.C., Snead, M.L. (2000)
The dentino-enamel junction is a broad transitional zone uniting dissimilar bioceramic
composites. Journal American Ceramic Society 83:238-240.
Moradian-Oldak, J., Paine, M.L., Lei, Y.P., Fincham, A.G., Snead, M.L. (2000) Self-assembly
of recombinant engineered amelogenin proteins analyzed by dynamic light scattering
and atomic force microscopy. Journal Structural Biology 131:27-37.
Zhou, Y.L., Snead, M.L. (2000) Identification of CCAAT/enhancer-binding protein alpha as a
transactivator of the mouse amelogenin gene. Journal of Biological Chemistry.
275:22284-22292.
Zhou YL, Lei Y, and Snead ML. (2000) Mouse amelogenin gene expression Is mediated by
protein-protein interactions: functional antagonism between Msx2 and
CCAAT/Enhancer-binding protein a (C/EBP-alpha). Journal of Biological Chemistry
275:29066-29075.
Paine CT, Paine ML, Luo W, Okamoto CT, Lyngstadaas SP, Snead ML. (2000) A tuftelininteracting
protein (TIP39) localizes to the apical secretory pole of mouse ameloblasts.
Journal of Biological Chemistry. 275:22284-92.
1999
Dhamija, S., Liu, Y., Yamada, Y., Snead, M.L., Krebsbach, P.H. (1999) Cloning and
characterization of the murine ameloblastin promoter. Journal of Biological Chemistry
274:20738-20743.
Liu, Y-H., Tang, Z., Kundu, R.K., Wu, L., Luo, W., Zhu, D., Sangiorgi, F., Snead, M.L.,
Maxson, R.E., Jr. (1999) Msx2 gene dosage influences the number of proliferative
osteogenic cells in growth centers of the developing murine skull: A possible mechanism
of Msx2-mediated craniosynostosis . Developmental Biology 205:260-274.
1998
Nanci A, Zalzal S, Lavoie P, Kunikata M, Chen W, Krebsbach PH, Yamada Y, Hammarstrom
L, Simmer JP, Fincham AG, Snead ML, Smith CE. (1998) Comparative
immunochemical analyses of the developmental expression and distribution of
ameloblastin and amelogenin in rat incisors. Journal Histochemistry Cytochemistry.
46:911-34.
Paine, M.L., Krebsbach, P.H., Chen, L.S., Paine, C.T., Yamada, Y., Deutsch, D. and Snead,
M.L. (1998) Protein to protein interactions: Criteria defining the assembly of the enamel
organic matrix. (In Press) J Dental Research 77:496-503.
MALCOLM L. SNEAD DDS PHD 23
Jaskoll T, Luo W, Snead ML. (1998) Msx-2 expression and glucocorticoid-induced
overexpression in embryonic mouse submandibular glands. J Craniofacial Genetics
Developmental Biology. 18:79-87.
1997
Snead, M.L. (1997) Protein interactions defined by the yeast two-hybrid system. Ciba
Foundation Symposium No. 205 Dental Enamel, (Eds. D.J. Chadwick and G Cardew)
pp148-150
Paine, M.L. and Snead, M.L. (1997) Protein interactions during assembly of the enamel
organic extracellular matrix. Journal Bone and Mineral Research 12:221-227.
Liu, Yi H, Ma, L., Kundu, R., Ignelzi, M., Sangiorgi, F.S., Wu, L., Luo, W., Snead, M.L., and
Maxson (1997) Function of the Msx2 gene in the morphogenesis of the skull. Annals
New York Academy of Science
Fincham, A.G., Baehner, R., Chai, Y., Crowe, D.L., Fincham, C., Iskander, M., Landesman,
H.M., Lee, M., Luo, W., Paine, M., Pereira, L., Moradian-Oldak, J., Rosenblum, A.,
Snead, M.L., Thompson, P., Wuenschell, C., Zeichner-David, M., and Shuler, C.F.
(1997) Problem based learning at the University of Southern California school of
dentistry. Journal of Dental Education 61:417-425.
1996
Snead, M.L. (1996) Enamel biology logodaedaly: Getting to the root of the problem, or
“Who’s on first....” Journal of Bone Mineral Research 11: 899-904.
Snead, M.L. Paine, M.L., Chen, L.S., Yoshida, B., Luo, W., Zhou, D., Lei, Y.P., Liu, Y.H., and
Maxson, R.E. (1996) The Murine Amelogenin Promoter: Developmentally Regulated
Expression in Transgenic Animals. Connective Tissue Research 35(1-4):41-47.
Paine, M.L., Deutsch, D. and Snead, M.L. Carboxyl-region of tuftelin mediates selfassembly.
Connective Tissue Research 35(1-4)157-161.
1995
Liu, Y.H., Ma, L., Kundo, R., Luo, W., Snead, M.L., and Maxson, R. (1994) Defining the
minimal promoter of MSX2 required for apical ectodermal ridge expression by
transgenic animals. Mechanisms in Development 48:187-197.
MacDougall, M., Thiemann, F., Ta, H., Hsu, P., Chen, L.S., and Snead, M. L. (1995)
Temperature sensitive simian virus 40 large T antigen immortalization of murine
odontoblast cell cultures: Establishment of clonal odontoblast cell line. Connective
Tissue Research 33:97-103.
MALCOLM L. SNEAD DDS PHD 24
Liu, Y.H., Kundu, R., Wu, L., Luo, W., Ignelzi, M.A., Snead, M.L. and Maxson, R.E. (1995)
Premature suture closure and ectopic cranial bone in mice expressing MSX2 transgenes
in the developing skull. Proceedings of the National Academy of Science (USA)
92:6137-6141.
Ignelzi, M.A. Jr., Liu, Y.H., Maxson, R.E. Jr. and Snead, M.L. (1995) Genetically Engineered
Mice: Tools to understand craniofacial development. Critical Reviews Oral Biology and
Medicine 6:181-201.
Zeichner-David, M., Diekwisch, T., Fincham, A., Lau, E., MacDougall, M., Moradian-Oldak, J.,
Simmer, J., Snead, M.L. and Slavkin, H.C. (1995) Control of ameloblast differentiation.
Int. J. Dev. Biol. 39:69-92.
1994
Liu, Y.H., Ma, L., Wu, L.Y., Luo, W., Kundu, R., Sangiorgi, F., Snead, M.L., and Maxson, R.
Regulation of the Msx2 homeobox gene during mouse embryogenesis: A transgene with
439 bp of 5’ flanking sequence is expressed exclusively in the apical ectodermal ridge of
the developing limb. Mechanisms of Development 48:187-197 (1994)
Couwenhoven, R.I. and Snead, M.L. Instructive versus permissive influences in enamel
organ epithelial differentiation of the mouse mandibular first molar. Developmental
Biology 164:290-299 (1994)
Tong, H-S., Sakai, D.D., Sims, S.M., Dixon, S.J., Goldring, S.R., Yamin, M., Snead, M.L., and
Minkin, C. Murine osteoclasts and spleen cell polykaryons are distinguished by mRNA
phenotyping. Journal Bone Mineral Research 9:577-584 (1994).
Simmer, J.P., Lau, E.C., Hu, C.C., Aoba, T., Lacey, M., Nelson, D., Zeichner-David, M.,
Snead, M.L., Slavkin, H.C. and Fincham, A.G. Isolation and characterization of a mouse
amelogenin expressed in Escherichia coli. Calcif. Tissue Int. 54:312-319 (1994)
1993
Bell, J.R., Noveen, A., Liu, Y.H., Ma, L., Dobias, S., Kundu, R., Luo, W., Xia, Y., Lusis, A.J.,
Snead, M.L., and Maxson, R. (1993) Genomic structure, chromosomal location, and
evolution of the mouse HOX 8 gene. Genomics 16:123-131.
Jabs, E. W., Muller, U., Li, X., Ma, L., Luo, W., Haworth, I.S., Klisak, I., Sparkes, R.,
Warman, M.L., Mulliken, J.B., Snead, M.L. and Maxson R. (1993) A Mutation in the
homeodomain of the human MSX2 gene in a family affected with autosomal dominant
craniosynostosis. Cell 75:443-450.
Couwenhoven, R.I., Schwartz, S.A. and Snead, M.L. (1993) Arrest of amelogenin
transcription activation in bromodeoxyuridine treated developing mouse molars in vitro.
Journal Craniofacial Genetics and Developmental Biology, 13:259-269.
Shum, L., Sakakura, Y., Bringas,, P., Luo, W., Snead, M.L., Mayo, M., Crohin, C., Milar, S.,
Werb, Z., Buckley, S., Hall, F.L., Warburton, D., and Slavkin, H.C. (1993) EGF
MALCOLM L. SNEAD DDS PHD 25
abrogation-induced fusilli-form dysmorphogenesis of Meckel's cartilage during
embryonic mouse mandibular morphogenesis in vitro. Development 118:903-917.
1992
Gollard, R.P., Slavkin, H.C., and Snead, M.L. (1992) Polyoma virus induced murine
odontogenic tumors. Oral Surgery, Oral Medicine and Oral Pathology, 74:761-767.
Watson, J.M., Spencer, J.A., Graves, M. J.A., Snead, M.L. and Lau, E.C. (1992) Autosomal
localization for the amelogenin gene in monotremes and marsupials: Implications for
mammalian sex chromosome evolution. Genomics 14:785-789.
Lau, E.C., Simmer, J.P., Bringas, P., Hsu, D.D-J., Hu, C-C., Zeichner-David, M., Thiemann,
F., Snead, M.L., Slavkin, H.C., and Fincham, A.G. (1992) Alternative splicing of the
mouse amelogenin primary RNA transcript contributes to amelogenin heterogeneity.
Biochem. Biophy Res Comm 188: 1253-1260.
Chen, L.S., Couwenhoven, R.I., Hsu, D. D-J, Luo, W. and Snead, M.L. (1992) Maintenance
of amelogenin gene expression by transformed mouse enamel oral epithelial cells.
Archives Oral Biology 37:771-778.
Raaberg, L., Nexo, E., Buckley, S., Luo, W., Snead, M.L., and Warburton, D. (1992)
Epidermal growth factor: A novel autocrine mechanism in rat type II pneumocytes.
American Journal of Respiratory Cell and Molecular Biology 6:44-49.
Snead, M.L., Luo, W., Hsu, Dora, D-J, Melrose, R.J., Lau, E.C., and Stenman, G. (1992)
Human ameloblastoma tumors express the amelogenin gene. Oral Surgery, Oral
Medicine and Oral Pathology 74:64-72.
Jepsen, S., Schiltz, P., Strong, D.D., Scharla, S.H., Snead, M.L. and Finkelman, R.D. (1992)
Transforming growth factor beta 1 mRNA in neonatal ovine molars visualized by in situ
hybridization: Potential role for the stratum intermedium. Archives of Oral Biology
37:645-653.
1991
Fincham, A.G., Hu, Y., Lau, E.C., Slavkin, H.C. and Snead, M.L. (1991) Amelogenin postsecretory
processing during biomineralization in the postnatal mouse molar. Arch. oral
Biol. 36:305-317.
Chapman, V., Keitz, C., Stephenson, M., Lau, E.C., and Snead, M.L.: (1991) Linkage of
AMELOGENIN to the distal portion of the mouse X-chromosome. Genomics 10:23-28.
Luo, W., Slavkin, H.C. and Snead, M.L.: (1991) Cells from Hertwig's epithelial root sheath do
not transcribe amelogenin. J. Perio. Res. 26:42-47
Kidd, V.J., Luo, W., Xiang, J., Tu, F., Easton, J., McCune, S., Snead, M.L. (1991) Regulated
expression of a cell division control-related protein kinase during development. Cell
Growth & Differentiation. 2:85-93
1990
MALCOLM L. SNEAD DDS PHD 26
Lau, E.C., Slavkin, H.C. and Snead, M.L. (1990) Analysis of human enamel genes: Insights
into genetic disorders of enamel. The Cleft Palate Journal 27:121-130.
Fincham, A.G., Hu, Y., Lau, E., Pavlova, Z., Slavkin, H.C. and Snead, M.L. (1990) Isolation
and partial characterization of a human amelogenin from a single fetal dentition using
HPLC techniques. Calcif Tissue Int 47:105-111
Couwenhoven, R.I. Luo, W., and Snead, M.L. (1990) Co-localization of EGF transcripts and
peptides by combined immunohistochemistry and in situ hybridization. J. Histochem.
and Cytochem 38:1853-1857.
1989
Snead, M.L., Lau, E.C., Fincham, A.G., Zeichner-David, M., Davis, C. and Slavkin, H.C.
(1989). Of mice and men: Anatomy of the amelogenin gene. Connective Tissue
Research 22:101-109.
Zeichner-David, M., MacDougall, M., Davis, A., Vides, J., Snead, M.L., and Slavkin, H.C.
(1989). Enamelins and amelogenins share the same amino-terminal sequence.
Connective Tissue Research 22:123-129.
Snead, M.L., Luo, W., Oliver, P., Nakamura, M., Don-Wheeler, G., Bessem, C., Bell, G.I.,
Rall, L.B., and Slavkin, H.C. (1989) Localization of epidermal growth factor precursor in
tooth and lung during embryonic mouse development. Developmental Biology
134(2):420-429.
Amar, S., Luo, W., Snead, M.L., and Ruch, J.V. (1989) Amelogenin gene expression in
mouse incisor heterotypic recombinations. Differentiation 41:56-61.
Couwenhoven, R., Davis, C., and Snead, M.L. (1989) Mouse ameloblasts do not transcribe
the albumin gene. Calcified Tissue International 45:367-371.
Fincham, A.G., Hu, Y., Pavlova, Z., Slavkin, H.C., and Snead, M.L. (1989) Human
amelogenins: sequences of "TRAP" molecules. Calcified Tissue International 45:243-
250.
Fincham, A.G., Bessem, C., Bringas, P., Hu, Y., Snead, M.L., and Slavkin, H.C. (1989)
Amelogenesis in vitro: a model for studies of post-secretory processing during enamel
biomineralization. Differentiation 41:62-71.
Zeichner-David, M., MacDougall, M., Davis, A., Vides, J., Snead, M.L., and Slavkin, H.C.
(1989) Enamelins and amelogenins share the same amino-terminal sequence.
Connective Tissue Research 22:123-129.
Snead, M.L., Lau, E.C., Fincham, A.G., Zeichner-David, M., Davis, C. and Slavkin, H.C.
(1989) Of mice and men: Anatomy of the amelogenin gene. Connective Tissue
Research 22:101-109.
MALCOLM L. SNEAD DDS PHD 27
Luo, W., Roop, D.R., Lau, E.C., Melrose, R.J., Mostofi, R., Stenman, G., and Snead, M.L.
(1989) In situ hybridization Analysis of Keratin Gene Expression In Human
Ameloblastomas. J. Oral Pathology 17:534-540.
Slavkin, H.C., Bringas, P., Bessem, C., Santos, V., Nakamura, M., Hsu, M, Snead, M.L.,
Zeichner-David, M., and Fincham, A.G. (1989) Hertwig's epithelial root sheath
differentiation and initial cementum and bone formation during long-term organ culture of
mouse mandibular first molars using serum-less, chemically-defined medium. Journal of
Periodontal Research 23:28-40.
Slavkin, H.C., Bessem, C., Fincham, A.G., Bringas, P., Santos, V., Snead, M.L., and
Zeichner-David, M. (1989) Human and mouse cementum proteins immunologically
related to enamel proteins. Biochimica et Biophysica Acta 991:12-18.
Lau, E.C., Mohandas, T.K., Shapiro, L.J., Slavkin, H.C., and Snead, M.L. (1989) Human and
mouse amelogenin gene loci are on the sex chromosomes. Genomics 4:162-168.
1988
Snead, M.L., Luo, W., Lau, E.C., and Slavkin, H.C. (1988) Spatial- and temporal-restricted
pattern for amelogenin gene expression during mouse molar tooth organogenesis.
Development 104:77-85.
Slavkin, H.C., Bessem, C., Bringas, P., Zeichner-David, M., Nanci, A., and Snead, M.L.
(1988) Sequential expression and differential function of multiple enamel proteins during
fetal, neonatal and early postnatal stages of mouse molar organogenesis.
Differentiation 33:26-39.
Slavkin, H.C., MacDougall, M., Zeichner-David, M., Oliver, P.., Nakamura, M., and Snead,
M.L. (1988) Molecular determinants of cranial neural crest-derived odontogenic
ectomesenchyme during dentinogenesis. Amer J. Medical Genetics 4:7-22.
Zeichner-David, M., Vides, J., MacDougall, M., Fincham, A., Snead, M.L., Bessem, C., and
Slavkin, H.C. (1988) Biosynthesis and characterization of rabbit tooth enamel
extracellular matrix proteins. Biochem J. 251:631-641.
1987
Snead, M.L. and Lau, E. (1987) Examining the possible molecular origins for enamel protein
complexity. Advances In Dental Research 1:298-305.
Lau, E.C., Bessem, C.C., Slavkin, H.C., Zeichner-David, M., and Snead, M.L. (1987)
Amelogenin antigenic domain defined by clonal epitope selection. Calcif. Tissue Int.
40:231-237.
Zeichner-David, M., MacDougall, M., Vides, J., Snead, M. L., Slavkin, H.C., Turkel, S., and
Pavlova, Z. (1987) Immunochemical and biochemical studies of human enamel proteins
during neonatal development. Journal Dental Research 66:50-56.
MALCOLM L. SNEAD DDS PHD 28
1985 and Earlier
Snead, M.L., Lau, E.C., Zeichner-David, M., Fincham, A.G., Woo, S.L.C., and Slavkin, H.C.
(1985) DNA sequence for cloned cDNA for murine amelogenin reveal the amino acid
sequence for enamel-specific protein. Biochemical and Biophysical Research
Communications 129:812-818.
Slavkin, H.C., Snead, M.L., Zeichner-David, M., Jaskoll, T.F., and Smith, B.T. (1984)
Concepts of epithelial-mesenchymal interactions during development: tooth and lung
organogenesis. J. Cellular Biochemistry 26:117-125.
Snead, M.L., Bringas, P.,Jr., Bessem, C., and Slavkin, H.C. (1984) De novo gene induction
detected by amelogenin gene transcript analysis, in vivo. Developmental Biology
104:255-258.
Snead, M.L., Zeichner-David, M., Chandra, T., Robson, K.J.H., Woo S.L.C., and Slavkin,
H.C. (1983) Construction and identification of a mouse amelogenin cDNA clone. Proc.
Natl. Acad. Sci. (USA) 80:7254-7258.
Schwartz, S.A. and Snead, M.L. (1982) BrdU-DNA interactions during odontogenesis, in
vitro. Arch. Oral Biology 27:9-12.
Snead, M.L. (1981) Examinations and characterization of extracellular matrix components
requisite for odontogenesis, in vitro. Doctoral Dissertation, University of Chicago.
Snead, M.L. and Schwartz, S.A. (1980) Effect of 5 bromodeoxyuridine on extra-cellular matrix
during odontogenesis in vitro. Virchows Archiv 33:35-46.
Chapters in Books:
Snead, M.L., (2003) Enhancing the processes of discovery and innovation for optimal host
response at implant surfaces. (Eds, Jan Eirik Ellingsen and S Petter Lyngstadaas), CRC
Press.
Fincham, A.G., Moradian-Oldak, J., Paine, M.L., Snead, M.L. and Zeichner-David, M. (2000),
Enamel Biomineralization: The assembly and disassembly of the protein extracellular
organic matrix. In: Development, Function and Evolution of Teeth. (Eds. M.F. Teaford,
Moya Merideth Smith and Mark W.J. Ferguson) Cambridge University Press.
Snead, M.L. (1997) Application of the yeast two hybrid system to enamel protein assembly.
In: Dental Enamel (H.C. Slavkin and G.B. Winter) Ciba Foundation.
Snead, M.L. (1997) Analysis of the mouse amelogenin promoter. In: Dental Enamel (H.C.
Slavkin and G.B. Winter) Ciba Foundation.
Simmer, J.P. and Snead, M.L. (1995) Molecular biology of the amelogenin gene. In: Dental
Enamel: Formation to Destruction (C. Robinson, J. Kirkham and R. Shore, eds), CRC
Press.
Slavkin, M.L., Kresja, R.J., Fincham, A.G., Bringas, P., Santos, V., Sasano, Y., Snead, M.L.,
and Zeichner-David, M. (1991) Evolution of enamel proteins: A paradigm for
mechanisms of biomineralization. In: Mechanisms and Phylogeny of Mineralization in
Biological Systems (S. Suga and N. Nakahara, eds), Springer-Verlag,pp 383-389.
MALCOLM L. SNEAD DDS PHD 29
Snead, M.L., Lau, E.C, Fincham, A.G., Zeichner-David, M., and Slavkin, H.C. (1989)
Knowledge based molecular dissection of amelogenesis: The chromosomal location of
the amelogenin genes. In: Tooth Enamel V (R.W. Fearnhead, ed.), Florence Publishers,
Yokohama Japan, pp 261-269.
Snead, M.L., Lau, E.C., Fincham, A.G., Zeichner-David, M., Davis, C. and Slavkin, H.C.
(1989). Of mice and men: Anatomy of the amelogenin gene. In: The Chemistry and
Biology of Mineralized Tissue (M. Glimcher, ed.) Pergamommom Press, New York,
pp727-735
Zeichner-David, M., MacDougall, M., Davis, A., Vides, J., Snead, M.L., and Slavkin, H.C.
(1989). Enamelins and amelogenins share the same amino-terminal sequence. In: The
Chemistry and Biology of Mineralized Tissue (M. Glimcher, ed.) Pergamommom Press,
New York, pp 749-757.
Fincham, A.G., Hu, Y., Lau, E.C., Slavkin, H.C. and Snead, M.L. (1991) Amelogenin postsecretory
processing during biomineralization in the postnatal mouse molar. Arch. oral
Biol. 36:305-317.
Slavkin, H.C., Snead, M.L., Luo, W., Bringas, P., Kikunaga, S., Sasano, Y., Bessem, C.,
Mayo, M., MacDougall, M., Rall, L.B., Rappolee, D., and Werb, Z. (1989) Analysis of
embryonic cartilage and bone induction in a defined culture system. In: Bone Regulatory
Factors: Morphology, Biochemistry, Physiology and Pharmacology (A. Pecile and B.
deBernard, eds.) Plenum Publishing Co. Ltd.
Slavkin, H.C., Snead, M.L., Zeichner-David, M., MacDougall, M., Fincham, A., Lau, E.C., Luo,
W., Nakamura, M., Oliver, P., and Evans, J. (1987) Factors influencing expression of
dental ECM biomineralization. In: Cell and Molecular Biology of Hard Tissues (G. Rodan
and A. Caplan, eds.), John Wiley & Sons, Chichester, England. CIBA Foundation
Symposium 135.
Snead, M.L., Lau, E.C., Zeichner-David, M., Nanci, A., Bendayan, M., Bringas, P.,Jr.,
Bessem, C., and Slavkin, H.C. (1987) Relationship of the ameloblast biochemical
phenotype to morpho- and cyto-differentiation. In: Molecular Approaches To
Development Biology (E. Davidson and N. Firtel, eds.), Alan R. Liss, Inc., New York pp.
641-652.
Snead, M.L., Zeichner-David, M., Lau, E. DiLella, A., Woo, S.L.C., and Slavkin, H.C. (1985)
Enamel gene expression in selected vertebrates using nucleic acid hybridization probes.
In: Second International Conference on the Chemistry and Biology of Mineralized
Tissues (W.T.Butler, ed.), Elsevier, North Holland, New York pp. 270-273.
Zeichner-David, M., Vides, J., Snead, M.L., and Slavkin, H.C. (1985) Enamel protein
characterization by mRNA translation in a cell-free system. In: Second International
Conference on the Chemistry and Biology of Mineralized Tissues (W.T. Butler, ed.), pp
264-270.
Slavkin, H.C., Snead, M.L., Zeichner-David, M., Bringas, P., Jr., and Greenberg, G.L. (1984)
Amelogenin gene expression during epithelial-mesenchymal interactions. In: The Role
of Extracellular Matrix in Development (R.L. Trelstad, ed.), Alan R. Liss, Inc., New York
pp. 221-253.
Slavkin, H.C., Zeichner-David, M., Snead, M.L., Graham, E.E., Samuel, N., and Ferguson,
M.W.J. (1984) Amelogenesis in reptilia: evolutionary aspects of enamel gene products.
In: Structure, Function and Evolution of Reptiles (M.W.J. Ferguson, ed.), Academic
Press, Ltd., London, pp. 275-303.
Slavkin, H.C., Snead, M.L., Zeichner-David, M., Jaskoll, T.F., and Smith, B.T. (1984)
Concepts of epithelial-mesenchymal interactions during development: tooth and lung
MALCOLM L. SNEAD DDS PHD 30
organogenesis. In: Proceeding of the 1984 UCLA Symposia on Extracellular Matrix:
Structure and Function (A.H. Reddi, ed.), Alan Liss, New York pp. 275-303.
Slavkin, H.C., Zeichner-David, M., Snead, M.L., Bringas, P., Jr., Bessem, C., and Santos, V.
(1984) Epithelial-mesenchymal interactions and enamel gene inductions. In: Tooth
Enamel IV (R.W. Fearnhead and S. Suga, eds.), Elsevier/North Holland Publishers,
Amsterdam pp. 167-171.
Slavkin, H.C., Zeichner-David, M., Snead, M.L., Samuel, N., Bessem, C., and Bringas, P.
(1984) Genetic and phylogenetic aspects of enamel. In: Tooth Morphogenesis and
Differentiation (J.V. Ruch and A. Belcourt, eds.), INSERM, Paris, France 126:341-354.
Snead, M.L., Lidskey, A.S., DiLella, A.D., Zeichner-David, M., Woo S.L.C., and Slavkin, H.C.
(1984) Of mice and men: the cloning of enamel gene sequences. In: Tooth
Morphogenesis and Differentiation (J.V. Ruch, ed.), INSERM, Paris, France, pp. 363-
368.
Snead, M.L., Zeichner-David, M., Woo, S.L.C., and Slavkin, H.C. (1984) Construction and
identification of molecular clones to mouse enamel proteins: the anatomy and
physiology of the enamel genes. In: Tooth Enamel IV (R.W. Fearnhead and S. Suga,
eds.), Elsevier/North Holland Publishers, Amsterdam pp 172-176.
Zeichner-David, M., Vides, J., Snead, M.L., and Slavkin, H.C. (1984) Enamel gene
expression in selected vertebrates. In: Tooth Enamel IV (R.W. Fearnhead and S. Suga,
eds.), Elsevier North Holland Publishers, Amsterdam, pp 183-187.
Zeichner-David, M., Snead, M.L., and Slavkin, H.C. (1984) Genetic differences in enamel
gene products amongst mammalian species. In: Tooth Morphogenesis and
Differentiation (J.V. Ruch, ed.), INSERM, Paris, France 125:355-362.
ABSTRACTS
To preserve space no abstracts are listed.
OTHER
Snead, M.L. Developmental biology and pathobiology: Fusion through molecular biology.
Invited Guest Editorial, Journal of Dental Research (1989).
Snead, M.L. Enamel Biology Logodaedaly: Getting to the Root of the Problem, or "Who's on First..."
Invited Guest Editorial, Journal of Bone and Mineral Research (1996).
Selected Presentations
2015 Visiting Faculty Member
Xi'an Jiaotong University, Xi’an, China
2015 International Conference on the Characterization and Control of
Interfaces, Kurashiki, Japan
Plenary Address, Symposium on Powder Technology and Smart
Processing
2014 International Symposium on Biomimetic Materials Processing
Nagoya University, Nagoya, Japan
2013 University of Tsukuba, Institute of Materials Science, School of
Engineering, Tsukuba, Japan
2013 1st International Workshop on Solution Plasma and Molecular
Technologies (SPM1), Shibaura Institute of Technology, Tokyo,
Japan
2013 International Symposium on Biomimetic Materials Processing
Nagoya University, Nagoya, Japan
2013 Materials Research Society of Japan
International Union of Materials Research Societies
2012 Gordon Research Conference
Discussion Leader, Biomineralization
2012 Biomimetic Materials Processing Symposium (BMMP)
Nagoya University, Japan
2011 Gordon Research Conference
Discussion Leader, Biomineralization
2010 Gordon Research Conference
Discussion Leader, Biomineralization
2010 Scandanavian Society of Biomaterials, Norway
2010 Ecotopia, Nagoya, Japan
2006 National Science Foundation- MRSEC
Genetically Engineered Peptides in Engineering
2006 Gordon Research Conference
“Signal Transduction by Engineered Extracellular Matrices”
2005 8th International Conference on the Chemistry and Biology of
Mineralized Tissues.
2004 Gordon Research Conference
“Biomineralization”
2003 National Institute for Dental and Craniofacial Research
“Hierarchical scale contributes to the unique materials properties of
enamel”
1997 American Association for the Advancement of Science
"Revolution in Dental Education"
1997 VIth International Conference on Tooth Morphogenesis
1997 Gordon Research Conference
"Saliva and Salivary Glands."
Discussion Leader
1996 Gordon Conference
"Biomineralization"
1996 Ciba Foundation Symposium No 205
Dental Enamel
1995 Third Carolina Conference on Tooth Enamel
1995 American Association for Dental Research
“Homeobox Genes and Craniofacial Malformations”
1993 Gordon Conference, "Bones and Teeth"
1992 Fourth International Conference on the "Biology and Chemistry of
Mineralized Tissues".
MALCOLM L. SNEAD DDS PHD 14
1991 National Institute of Dental Research,
Workshop on "The Genetic Diseases of the Craniofacial Oral-Dental
Complex".
1990 University of California San Francisco
Graduate Program in Oral Biology
1990 West Coast Regional Developmental Biology Meeting
1989 International Association for Dental Research,
Symposia Speaker: "The Genomes of Bone and Teeth".
1989 The American Academy of Oral Pathology
1989 Tooth Enamel Symposium V: The Composition Properties and
Fundamental Structure of Tooth Enamel
1988 The Third International Conference
on the Chemistry and Biology of Mineralized Tissues
1987 The University of Chicago
The Zoller Lecture Series
1987 The Second Carolina Conference
on Tooth Enamel Formation
1987 The American Academy of Oral Pathology
1986 Gordon Conference, "Bones and Teeth"
1985 International Association for Dental Research, Symposia Speaker
1984 Tooth Enamel Symposium IV: The Composition Properties and
Fundamental Structure of Tooth Enamel
Selected Awards & Honors
AWARDS & FELLOWSHIPS
2010 Mellon Faculty Mentoring Award
University of Southern California
2007 Fulbright Senior Specialist Program
Developmental Biology and Paleoanthropology
University of Witwatersrand, South Africa
2001 Research in Oral Biology Award
International Association for Dental Research
2000 MERIT Award, National Institutes of Health
National Institute of Dental and Craniofacial Research,
1995 Fellow, American Association for the Advancement of Science
1985-1990 Research Career Development Award
United States Public Health Service
1988 Visiting Scientist Fellowship
Dana Farber Cancer Institute
Molecular Biology Computer Research Resource
1977-1979 Walter G. Zoller Fellow
The University of Chicago
Chicago, Illinois
1976-1977 Johnson and Johnson Fellow