All seminars take place on Mondays from 4:00 pm - 5:00 pm in LEEP2 2420, unless otherwise specified.
4:00pm in LEEP2 2420
Abstract: Antivascular therapy represents a proven strategy to improve the prognosis of a variety of pathological conditions, including cancer and many eye diseases. By synergistically applying laser pulses and ultrasound bursts, we developed a novel photo-mediated ultrasound therapy (PUT) technique as a localized antivascular method. PUT takes advantages of the high native optical contrast between biological tissues, and has the unique capability to self-target microvessels without causing unwanted damages to the surrounding tissue. Through in vitro experiments and theoretical simulations, we demonstrate that cavitation might have played a key role in PUT. In animal experiments, we demonstrate that PUT can treat microvessels in target tissue via different mechanisms, which include blocking microvessels by inducing blood clots and disrupting microvessels by causing local hemorrhage. Moreover, PUT working at different optical wavelengths can selectively treat veins or arteries by utilizing the contrast in the optical spectra between deoxy- and oxy-hemoglobin. Specifically, PUT can be applied to precisely remove choroidal blood vessels in the eye, and result in significantly reduced blood perfusion in the choroidal layer which persisted to four weeks without causing collateral tissue damage, demonstrating that PUT is capable of removing choroidal microvasculature safely and effectively. With its unique advantages, PUT holds great potential for the clinical management of eye diseases associated with microvessels and neovascularization.