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  • Malcolm L. Snead D.D.S., PH.D.

Malcolm L. Snead D.D.D, PH.D.

University of Southern California - Laboratory Developmental Biology
Primary office:
332-442-3178
Center for Craniofacial Molecular Biology
Univeristy of Southern California
2250 Alcazar Street, CSA 142
Los Angeles, California 90033


Titles

Chair, Division of Biomedical Sciences

Herman Ostrow School of Dentistry

University of Southern California

Associated Tracks

Biomedical Sciences with special training in Pathology and Biomaterials

Research Interests

Amplifying cell signals for potentially lower cost stem cell interventions
 

 

Education

UNIVERSITY EDUCATION

Secondary Doctoral Degree &

Postdoctoral Education:

1981-1982 University of Southern California

Laboratory Developmental Biology

University Park MC-0191

Los Angeles, California, 90089-0191

Mentor: Dr. Harold C. Slavkin

1982 Baylor College of Medicine

Howard Hughes Medical Institute

Houston, Texas

Mentor: Dr. Savio L.C. Woo

1977-1981 The University of Chicago

Department of Pathology

Chicago, Illinois

Doctor of Philosophy, 1981

Mentor: Dr. Stephen A. Schwartz

1977-1979 The University of Chicago

The Zoller Dental Clinic

Chicago, Illinois

Oral Pathology: Board Eligible

Chief Resident 1979

Certificate 1979

Board Eligible

Mentors: Dr. Robert Goepp and Dr. Reza Mostofi

Primary Doctoral Degree:

1973-1977 Loyola University, School of Dentistry

Chicago, Illinois

Doctor of Dental Surgery, 1977

Undergraduate Education:

1969-1973 Saint Mary's College of California

Moraga, California

Bachelor of Science, 1973

Teaching

1995 to present Creation of Problem Based Learning Curriculum

Pilot Curriculum-USC Dental School

1995 to present Lecturer

Biochemistry and Molecular Biology

School of Dentistry

The University of Southern California

1996 to present Co-Director and Co-Developer (with Dr. S. Tahara)

Ethics in Research

Graduate School

The University of Southern California

1995 to present Director and Developer

Biomineralization

Graduate School

The University of Southern California

1994 to present Co-Director

Infectious Diseases

School of Dentistry

The University of Southern California

1992 to present Participant

Molecular Genetics of Embryonic Development

Biochemistry and Molecular Biology

The University of Southern California

School of Medicine

1992 to present Course Co-Director and Co-Developer

(With Charles Shuler)

Molecular Oral Pathology

Craniofacial Biology Program

The University of Southern California

School of Dentistry

1992 Course Director

Pathology

Second Year Undergraduate Students

The University of Southern California

School of Dentistry

1990 to present Course Director and Developer

Grand Rounds (Faculty Re-Development)

University of Southern California

School of Dentistry

1990 to present Course Co-Director and Co-Developer (with Dr. H.C. Slavkin)

Molecular Developmental Biology

Department of Biology

3 contact hours/week

The University of Southern California

1985-1990 Course Director and Developer

Advanced Oral Histology

2 contact hours/week

The University of Southern California

School of Dentistry

1984-1985 Participant

Human Development and Genetics,

6 contact hours

The University of Southern California

School of Dentistry

1984-1985 Participant

Pathophysiology of Human Diseases

MALCOLM L. SNEAD DDS PHD 12

4 contact hours

The University of Southern California

School of Dentistry

1979-1982 Participant

Oral Pathology

6 contact hours/week

Loyola University

School of Dentistry

1981-1983- Course Director and Developer

Current Topics in Molecular Biology

4 contact hours/week

Loyola University

School of Dentistry

1979-1980 Participant

Cell Pathophysiology

12 contact hours/week

The University of Chicago

Pritzker School of Medicine

CONTINUING MEDICAL EDUCATION

2010 Academy of Microscope Enhanced Dentistry

2009 American Association of Oral and Maxillofacial Surgeons

1999-2002 University of Southern California

Training Facilitators in Problem Based Learning

1999 University of Washington

Engineered Biomaterials Program

1999 University of Chicago

Department of Surgery

1998 University of Oslo, Oslo, Norway

European Dental Enamel Symposia

1997 University of Michigan, Ann Arbor Oral Health Science Seminars

1996 University of California, Los Angeles Molecular Biology Series

1995 University of Maryland, Baltimore College of Dental Surgery

1995 State University of New York, Buffalo Department of Oral Biology

1995 American Association for Dental Research Transgenic Animal Models in Dental Research

1993 New Jersey University of Medicine and Dentistry School of Dentistry

1991 Department of Pathology Children's Hospital

1990 Department of Veterans Affairs Jerry L. Pettis Memorial Hospital

1990 The Forsyth Dental Center

1989 The University of Texas Health Science Center The University of Texas Dental Branch, Houston

1989 American Academy of Oral Pathology Methods in Molecular Biology: In situ Hybridization

Selected Publications

2015

A Proline-Rich Peptide Mimic Effects of EMD in Rat Oral Mucosal Incisional Wound Healing.,

Villa O, Wohlfahrt JC, Mdla I, Petzold C, Reseland JE, Snead ML, Lyngstadaas SP. J

Periodontol. 2015 Aug 7:1-18. [Epub ahead of print], PMID:26252748

Store-operated Ca2+ Entry Modulates the Expression of Enamel Genes., Nurbaeva MK,

Eckstein M, Snead ML, Feske S, Lacruz RS, J Dent Res. 2015 Jul 31. pii:

0022034515598144. [Epub ahead of print], PMID:26232387

Hypoxia increases the expression of enamel genes and cytokines in an ameloblast-derived

cell line, Sidaly R, Landin MA, Suo Z, Snead ML, Lyngstadaas SP, Reseland JE. Eur J

Oral Sci. 2015 Jul 20. doi: 10.1111/eos.12201. [Epub ahead of print], PMID:26193448

Regulation of the Stem Cell-Host Immune System Interplay Using Hydrogel Coencapsulation

System with an Anti-Inflammatory Drug, Moshaverinia A, Chen C, Xu X, Ansari S,

Zadeh HH, Schricker SR, Paine ML, Moradian-Oldak J, Khademhosseini A, Snead ML,

Shi S., Adv Funct Mater. 2015 Apr 15;25(15):2296-2307. PMID:26120294

Protein Interaction between Ameloblastin and Proteasome Subunit α Type 3 Can Facilitate

Redistribution of Ameloblastin Domains within Forming Enamel, Geng S, White SN,

Paine ML, Snead ML., J Biol Chem. 2015 Aug 21;290(34):20661-73. doi:

10.1074/jbc.M115.640185. Epub 2015 Jun 12., PMID:26070558

MALCOLM L. SNEAD DDS PHD 15

Chimeric Peptides as Implant Functionalization Agents for Titanium Alloy Implants with

Antimicrobial Properties, DT Yucesoy, M Hnilova, K Boone, PM Arnold, ML Snead and

C Tamerler, April 2015, JOM, 67, 4, pp 754-766

Biomineralization of a Self-assembled, Soft-Matrix Precursor: Enamel, Malcolm L. Snead,

April 2015, JOM, 67, 4, pp 788-795

Bio-inspired hard-to-soft interface for implant integration to bone. Zhou Y, Snead ML,

Tamerler C. Nanomedicine. 2014 Nov 22. pii: S1549-9634(14)00554-1. doi:

10.1016/j.nano.2014.10.003. PMID: 25461292

High-fluoride promoted phagocytosis-induced apoptosis in a matured ameloblast-like cell line.

Yang T, Zhang Y, Zheng D, Hao Y, Snead ML, Duan X. Arch Oral Biol. 2015

Jan;60(1):84-90. doi: 10.1016/j.archoralbio.2014.09.001. Epub 2014 Sep 17. PMID:

25260155

2014

Comparison of two mouse ameloblast-like cell lines for enamel-specific gene expression.

Sarkar J, Simanian EJ, Tuggy SY, Bartlett JD, Snead ML, Sugiyama T, Paine ML. Front

Physiol. 2014 Jul 25;5:277. doi: 10.3389/fphys.2014.00277. eCollection 2014.

PMID:25120490

Concise review: mesenchymal stromal cells used for periodontal regeneration: a systematic

review. Monsarrat P, Vergnes JN, Nabet C, Sixou M, Snead ML, Planat-Bénard V,

Casteilla L, Kémoun P. Stem Cells Transl Med. 2014 Jun;3(6):768-74. doi:

10.5966/sctm.2013-0183. Epub 2014 Apr 17. Review. PMID: 24744392

Application of stem cells derived from the periodontal ligament or gingival tissue sources for

tendon tissue regeneration. Moshaverinia A, Xu X, Chen C, Ansari S, Zadeh HH, Snead

ML, Shi S. Biomaterials. 2014 Mar;35(9):2642-50. doi:

10.1016/j.biomaterials.2013.12.053. Epub 2014 Jan 4. PMID: 24397989

A model for the molecular underpinnings of tooth defects in Axenfeld-Rieger syndrome. Li X,

Venugopalan SR, Cao H, Pinho FO, Paine ML, Snead ML, Semina EV, Amendt BA.

Hum Mol Genet. 2014 Jan 1;23(1):194-208. doi: 10.1093/hmg/ddt411. Epub 2013 Aug

23. PMID: 23975681

2013

Dental mesenchymal stem cells encapsulated in an alginate hydrogel co-delivery

microencapsulation system for cartilage regeneration. Moshaverinia A, Xu X,

Chen C, Akiyama K, Snead ML, Shi S. Acta Biomater. 2013 Dec;9(12):9343-50. doi:

10.1016/j.actbio.2013.07.023. Epub 2013 Jul 26. PMID: 23891740

Co-encapsulation of anti-BMP2 monoclonal antibody and mesenchymal stem cells in

alginate microspheres for bone tissue engineering. Moshaverinia A, Ansari S,

Chen C, Xu X, Akiyama K, Snead ML, Zadeh HH, Shi S. Biomaterials. 2013

Sep;34(28):6572-9. doi: 10.1016/j.biomaterials.2013.05.048. Epub 2013 Jun 14.

PMID: 23773817

MALCOLM L. SNEAD DDS PHD 16

Role of the NH2 -terminal fragment of dentin sialophosphoprotein in dentinogenesis.

Gibson MP, Liu Q, Zhu Q, Lu Y, Jani P, Wang X, Liu Y, Paine ML, Snead ML, Feng

JQ, Qin C. Eur J Oral Sci. 2013 Apr;121(2):76-85. doi: 10.1111/eos.12020. Epub

2013 Feb 7. PMID: 23489896

The role of bioactive nanofibers in enamel regeneration mediated through integrin signals

acting upon C/EBPα and c-Jun. Huang Z, Newcomb CJ, Zhou Y, Lei YP, Bringas P Jr,

Stupp SI, Snead ML. Biomaterials. 2013 Feb 8. doi:pii: S0142-9612(13)00082-3.

10.1016/j.biomaterials.2013.01.054. PMID:23398885

Biological response on a titanium implant-grade surface functionalized with modular peptides.

Yazici H, Fong H, Wilson B, Oren EE, Amos FA, Zhang H, Evans JS, Snead ML,

Sarikaya M, Tamerler C. Acta Biomater. 2013 Feb;9(2):5341-52. PMID: 23159566

2012

Biomimetic mineralization: the role of nanoscale architecture in supramolecular templating of

biomimetic hydroxyapatite mineralization (small 14/2012). Newcomb CJ, Bitton R,

Velichko YS, Snead ML, Stupp SI. Small. 2012 Jul 23;8(14):2194.PMID:22791330

Cementomimetics-constructing a cementum-like biomineralized microlayer via amelogeninderived

peptides. Gungormus M, Oren EE, Horst JA, Fong H, Hnilova M, Somerman

MJ, Snead ML, Samudrala R, Tamerler C, Sarikaya M. Int J Oral Sci. 2012 Jun;4(2):69-

77. PMID:22743342

Characterization of dental epithelial stem cells from the mouse ncisor with 2D and 3D

Platforms. Chavez MG, Yu W, Biehs B, Harada H, Snead ML, Klein OD. Tissue Eng

Part C Methods. 2012 PMID: 22742471

The circadian clock modulates enamel development. Lacruz RS, Hacia JG, Bromage TG,

Boyde A, Lei Y, Xu Y, Miller JD, Paine ML, Snead ML. J Biol Rhythms. 2012

Jun;27(3):237-45. PMID:22653892

The role of nanoscale architecture in supramolecular templating of biomimetic hydroxyapatite

mineralization. Newcomb CJ, Bitton R, Velichko YS, Snead ML, Stupp SI. Small. 2012

Jul 23;8(14):2195-202. PMID:22570174

Targeted overexpression of amelotin disrupts the microstructure of dental enamel.

Lacruz RS, Nakayama Y, Holcroft J, Nguyen V, Somogyi-Ganss E, Snead ML, White SN,

Paine ML, Ganss B. PLoS One. 2012;7(4). PMID:22539960

2011

Ameloblastin upstream region contains structural elements regulating transcriptional activity

in a stromal cell line derived from bone marrow. Tamburstuen MV, Snead ML, Reseland

JE, Paine ML, Lyngstadaas SP. Eur J Oral Sci. 2011 Dec;119 Suppl 1:286-92.

PMID:22243258

MALCOLM L. SNEAD DDS PHD 17

Epithelial-specific knockout of the Rac1 gene leads to enamel defects. Huang Z, Kim J,

Lacruz RS, Bringas P Jr, Glogauer M, Bromage TG, Kaartinen VM, Snead ML. Eur J

Oral Sci. 2011 Dec;119 Suppl 1:168-76. PMID:22243243

Identification of novel candidate genes involved in mineralization of dental enamel by

genome-wide transcript profiling. Lacruz RS, Smith CE, Bringasjr P, Chen YB, Smith

SM, Snead ML, Kurtz I, Hacia JG, Hubbard MJ, Paine ML. J Cell Physiol. PMID:

21809343

The role of cell surface markers and enamel matrix derivatives on human periodontal

ligament mesenchymal progenitor responses in vitro. Kémoun P, Gronthos S, Snead

ML, Rue J, Courtois B, Vaysse F, Salles JP, Brunel G. Biomaterials. 2011 32(30):7375-

88. PMID: 21784516

The influence of Leucine-rich amelogenin peptide on MSC fate by inducing Wnt10b

expression. Wen X, Cawthorn WP, MacDougald OA, Stupp SI, Snead ML, Zhou Y.

Biomaterials. 2011 32(27):6478-86. PMID: 21663957

Folding, assembly, and aggregation of recombinant murine amelogenins with T21I and P41T

point mutations. Bromley KM, Lakshminarayanan R, Lei YP, Snead ML, Moradian-

Oldak J. Cells Tissues Organs. 2011;194(2-4):284-90. PMID: 21540557

Structural analysis of a repetitive protein sequence motif in strepsirrhine primate amelogenin.

Lacruz RS, Lakshminarayanan R, Bromley KM, Hacia JG, Bromage TG, Snead ML,

Moradian-Oldak J, Paine ML. PLoS One. 2011 Mar 18;6(3):e18028. PMID: 21437261

A simplified genetic design for mammalian enamel. Snead ML, Zhu DH, Lei Y, Luo W,

Bringas PO Jr, Sucov HM, Rauth RJ, Paine ML, White SN. Biomaterials. 2011

Apr;32(12):3151-7. Epub 2011 Feb 5. PMID: 21295848

PERP regulates enamel formation via effects on cell-cell adhesion and gene expression.

Jheon AH, Mostowfi P, Snead ML, Ihrie RA, Sone E, Pramparo T, Attardi LD, Klein OD.

J Cell Sci. 2011 Mar 1;124(Pt 5):745-54. PMID: 21285247

Ameloblastin expression and putative autoregulation in mesenchymal cells suggest a role in

early bone formation and repair. Tamburstuen MV, Reseland JE, Spahr A, Brookes SJ,

Kvalheim G, Slaby I, Snead ML, Lyngstadaas SP. Bone. 2011 Feb 1;48(2):406-13.

PMID:20854943

2010

Serotonin and fluoxetine receptors are expressed in enamel organs and LS8 cells and

modulate gene expression in LS8 cells. Riksen EA, Stunes AK, Kalvik A, Gustafsson BI,

Snead ML, Syversen U, Lyngstadaas SP, Reseland JE. Eur J Oral Sci. 2010

Dec;118(6):566-73. doi: 10.1111/j.1600-0722.2010.00778.x. PMID: 21083617

Perturbed amelogenin secondary structure leads to uncontrolled aggregation in amelogenesis

imperfecta mutant proteins. Lakshminarayanan R, Bromley KM, Lei YP, Snead ML,

Moradian-Oldak J. J Biol Chem. 2010 Dec 24;285(52):40593-603. PMID: 20929860

MALCOLM L. SNEAD DDS PHD 18

Biological synthesis of tooth enamel instructed by an artificial matrix. Huang Z, Newcomb CJ,

Bringas P Jr, Stupp SI, Snead ML. Biomaterials. 2010 Dec;31(35):9202-11. PMID:

20869764

Full length amelogenin binds to cell surface LAMP-1 on tooth root/periodontium associated

cells. Zhang H, Tompkins K, Garrigues J, Snead ML, Gibson CW, Somerman MJ. Arch

Oral Biol. 2010 55(6):417-25. PMID: 20382373

A solution NMR investigation into the murine amelogenin splice-variant LRAP (Leucine-Rich

Amelogenin Protein). Buchko GW, Tarasevich BJ, Roberts J, Snead ML, Shaw WJ.

Biochim Biophys Acta. 2010;1804(9):1768-74. PMID: 20304108

2009

Dental enamel: genes define biomechanics. Rauth RJ, Potter KS, Ngan AY, Saad DM, Mehr

R, Luong VQ, Schuetter VL, Miklus VG, Chang P, Paine ML, Lacruz RS, Snead ML,

White SN. J Calif Dent Assoc. 2009;37(12):863-8. PMID: 20066874

Science is the fuel for the engine of technology and clinical practice. Snead ML, Slavkin HC.

J Am Dent Assoc. 2009;140 Suppl 1:17S-24S.PMID: 19723927

Enamel matrix proteins; old molecules for new applications. Lyngstadaas SP, Wohlfahrt JC,

Brookes SJ, Paine ML, Snead ML, Reseland JE. Orthod Craniofac Res.

2009;12(3):243-53. PMID: 19627527

Leucine-rich amelogenin peptide induces osteogenesis by activation of the Wnt pathway.

Warotayanont R, Frenkel B, Snead ML, Zhou Y. Biochem Biophys Res Commun.

2009;387(3):558-63. PMID:

2008

Wen, X., Zou, Y.M., Luo, W., Goldberg, M., Moats, R., Conti, P.S., Snead, M.L., and Paine,

M.L. Biglycan overexpression on tooth enamel formation in transgenic mice. The

Anatomical Record, 291, 1246-1253, 2008.

Paine, M.L., Snead, M.L., Wang, H.J., Abuladze, N., Pushkin, A., Liu, W., Kao, L.Y., Wall,

S.M., Kim, Y.H., and Kurtz, I. Role of NBCe1 and AE2 in secretory ameloblasts. Journal

of Dental Research, 87, 391-395, 2008.

2007

Zou, Y.M., Wang, H.J., Shapiro, J.L., Okamoto, C.T., Brookes, S.J., Lyngstadaas, S.P.,

Snead, M.L., and Paine, M.L. Determination of protein regions responsible for

interactions of amelogenin with CD63 and LAMP1. Biochemical Journal, 408, 347-354,

2007.

Tarasevich, B.J., Howard, C.J., Larson, J.L., Snead, M.L., Simmer, J.P., Paine, M., and

Shaw, W.J. The nucleation and growth of calcium phosphate by amelogenin. Journal of

Crystal Growth, 304, 407-415, 2007. (doi:10.1016/j.crysgro.2007.02.035)

MALCOLM L. SNEAD DDS PHD 19

White, S.N., Paine, M.L., Ngan, A.Y.W., Miklus, V.G., Luo, W., Wang, H.J. and Snead, M.L.,

Ectopic expression of Dsp during amelogenesis hardens bulk enamel. Journal of

Biological Chemistry, 282, 5340-5345, 2007.

Shapiro, J.L., Wen, X., Okamoto, C.T., Wang, H.J., Lyngstadaas, S.P., Goldberg, M., Snead,

M.L. and Paine, M.L. Cellular uptake of amelogenin, and its localization to CD63, and

Lamp1-positive vesicles. Cellular and Molecular Life Sciences, 64, 244-256, 2007.

2006

Snead, M.L., Zhu, D.H., Lei, Y.P., White, S.N., Snead, C.M., Luo, W., and Paine, M.L. Protein

self-assembly creates a nanoscale device for biomineralization. Materials Science and

Engineering: C, 26(8), 1296-1300, 2006.

Zhu, D.H., Paine, M.L., Luo, W., Bringas, P. Jr., and Snead, M.L. Altering biomineralization

by protein design. Journal of Biological Chemistry, 281, 21173-21182, 2006.

Wang, H.J., Tannukit, S., Shapiro, J.L., Snead, M.L. and Paine, M.L. Using the yeast twohybrid

assay to discover protein partners for the leucine-rich amelogenin peptide (LRAP)

and for tuftelin-interacting protein 11 (TFIP11). European Journal of Oral Sciences,

114(Suppl. 1), 276-279, 2006.

Swanson, E.C., Fong, H.K., Foster, B.L., Paine, M.L., Gibson, C.W., Snead, M.L., and

Somerman, M.J. Amelogenins regulate expression of genes associated with

cementoblasts in vitro. European Journal of Oral Sciences, 114(Suppl. 1), 239-243,

2006.

Bartlett JD, Ganss B, Goldberg M, Moradian-Oldak J, Paine ML, Snead ML, Wen X, White

SN and Zhou YL. (2006) Protein-protein interactions of the developing enamel matrix.

Curr Top Dev Biol. 74:57-115.

Zhu D, Paine ML, Luo W, Bringas P Jr. and Snead ML. (2006) Altering biomineralization by

protein design. J Biol Chem. 281(30):21173-82.

Bartold PM, Xiao Y, Lyngstaadas SP, Paine ML and Snead ML. (2006) Principles and

applications of cell delivery systems for periodontal regeneration. Periodontol 2000.

41:123-35.

Wang HJ, Tannukit S, Wen X, Shapiro JL, Snead ML and Paine ML. (2006) Using the yeast

two-hybrid assay to discover protein partners for the leucine-rich amelogenin peptide

and for tuftelin-interacting protein-11. Eur J Oral Sci. 114 Suppl 1:276-9.

Swanson EC, Fong HK, Foster BL, Paine ML, Gibson CW, Snead ML and Somerman MJ.

(2006) Amelogenins regulate expression of genes associated with cementoblasts in

vitro. Eur J Oral Sci. 114 Suppl 1:239-43.

Xu Y, Zhou YL, Ann DK, MacDougald OA, Shum L and Snead ML. (2006). Transcription

factor sumoylation and factor YY1 serve to modulate mouse amelogenin gene

expression. Eur J Oral Sci. 114 Suppl 1:169-77.

MALCOLM L. SNEAD DDS PHD 20

Xu Y, Zhou YL, Luo W, Zhu QS, Levy D, MacDougald OA, Snead ML. (2006) NF-Y and

CCAAT/enhancer-binding protein alpha synergistically activate the mouse amelogenin

gene. J Biol Chem. 281 (23):16090-16098.

2005

Paine ML and Snead ML. (2005) Tooth developmental biology: disruptions to enamel-matrix

assembly and its impact on biomineralization. Orthod Craniofac Res. 8(4):239-51.

White SN, Miklus VG, Chang PP, Caputo AA, Fong H, Sarikaya M, Luo W, Paine ML, Snead

ML. (2005) Controlled failure mechanisms toughen the dentino-enamel junction zone. J

Prosthet Dent. 94(4):330-5.

Plikus MV, Zeichner-David M, Mayer JA, Reyna J, Bringas P, Thewissen JG, Snead ML,

Chai Y, Chuong CM. (2005) Morphoregulation of teeth: modulating the number, size,

shape and differentiation by tuning Bmp activity. Evol Dev. 7(5):440-57.

Paine ML, Luo W, Wang HJ, Bringas P Jr, Ngan AY, Miklus VG, Zhu DH, MacDougall M,

White SN, Snead ML. (2005) Dentin sialoprotein and dentin phosphoprotein

overexpression during amelogenesis. J Biol Chem. 280(36):31991-8.

Wang H, Tannukit S, Zhu D, Snead ML, Paine ML. (2005) Enamel matrix protein

interactions. J Bone Miner Res. 20(6):1032-40.

Wen X, Lei YP, Zhou YL, Okamoto CT, Snead ML, Paine ML. Structural organization and

cellular localization of tuftelin-interacting protein 11 (TFIP11). (2005) Cell Mol Life Sci.

62(9):1038-46.

Kubota K, Lee DH, Tsuchiya M, Young CS, Everett ET, Martinez-Mier EA, Snead ML,

Nguyen L, Urano F, Bartlett JD. (2005) Fluoride induces endoplasmic reticulum stress

in ameloblasts responsible for dental enamel formation. J Biol Chem. 280(24):23194-

202.

2004

Luo W, Wen X, Wang HJ, MacDougall M, Snead ML, Paine ML. (2004). In vivo

overexpression of tuftelin in the enamel organic matrix. Cells Tissues Organs.

177(4):212-20.

Shaw WJ, Campbell AA, Paine ML, Snead ML. (2004). The COOH Terminus of the

Amelogenin, LRAP, Is Oriented Next to the Hydroxyapatite Surface. J Biol Chem.

279(39):40263-6

Paine ML, Zhu DH, Luo W, Snead ML. (2004). Overexpression of TRAP in the Enamel Matrix

Does Not Alter the Enamel Structural Hierarchy. Cells Tissues Organs, 176:7-16.

2003

MALCOLM L. SNEAD DDS PHD 21

Fong H, White SN, Paine ML, Luo W, Snead ML, Sarikaya M. (2003). Enamel structure

properties controlled by engineered proteins in transgenic mice. J Bone Miner Res.

18(11):2052-9

Snead ML. (2003). Amelogenin protein exhibits a modular design: implications for form and

function. Connect Tissue Res. 2003;44 Suppl 1:47-51.

Wu LY, Li M, Hinton DR, Guo L, Jiang S, Wang JT, Zeng A, Xie JB, Snead ML, Shuler C,

Maxson RE Jr, Liu YH. (2003). Microphthalmia Resulting from Msx2-Induced Apoptosis

in the Optic Vesicle. Invest Ophthalmol Vis Sci 44, 2404-2412.

Paine ML., Wang HJ and Snead ML. (2003). Amelogenin Self-Assembly and the Role of the

Proline Located within the Carboxyl-Teleopeptide. Connective Tissue Research,

44(Suppl. 1): 52-57.

Paine ML, Luo W, Zhu DH, Bringas P Jr, Snead ML. (2003). Functional domains for

amelogenin revealed by compound genetic defects. J Bone Miner Res 18(3):466-72

Paine ML, Wang HJ, Luo W, Krebsbach PH, Snead ML. (2003). A transgenic animal model

resembling amelogenesis imperfecta related to ameloblastin over-expression. J Biol

Chem 278:19447-52

2002

Dunglas, C., Septier, D., Paine, M.L., Zhu, D.H., Snead, M.L., and Goldberg, M. (2002).

Ultrastructure of forming enamel in mouse bearing a transgene that disrupts the

amelogenin self-assembly domains. Calcif Tissue Int ; 71(2):155-66

Jitpukdeebodintra, S., Chai, Y., and Snead ML. (2002). Developmental patterning of the

circumvallate papilla. Int. J. Dev. Biol. 46, 755-763.

Paine ML, Lei YP, Dickerson K, Snead ML. (2002). Altered Amelogenin Self-assembly Based

on Mutations Observed in Human X-linked Amelogenesis Imperfecta (AIH1). J Biol

Chem 277(19):17112-6

2001

Green PD, Hjalt TA, Kirk DE, Sutherland LB, Thomas BL, Sharpe PT, Snead ML, Murray JC,

Russo AF, Amendt BA. (2001) Antagonistic regulation of Dlx2 expression by PITX2 and

Msx2: implications for tooth development. Gene Expr. 9(6):265-281.

Paine ML, White SN, Luo W, Fong H, Sarikaya M, Snead ML. (2001) Regulated gene

expression dictates enamel structure and tooth function. Matrix Biol. 20(5-6):273-292.

White SN, Luo W, Paine ML, Fong H, Sarikaya M, Snead ML. (2001) Biological organization

of hydroxyapatite crystallites into a fibrous continuum toughens and controls anisotropy

in human enamel. J Dent Res. 80(1):321-326.

2000

MALCOLM L. SNEAD DDS PHD 22

Liu YH, Snead ML, Maxson RE. (2000) Transgenic mouse models of craniofacial disorders.

Methods Molecular Biology. 137:499-512.

Paine ML, Zhu DH, Luo W, Bringas P Jr., Goldberg M, White SN, Lei YP, Sarikaya M, Fong

HK, Snead ML. (2000) Enamel biomineralization defects result from alterations to

amelogenin self-assembly. J Structural Biology. 132:191-200.

White, S.N., Paine, M.L., Luo, W., Sarikaya, M., Fong, H., Yu, Z., Li, Z.C., Snead, M.L. (2000)

The dentino-enamel junction is a broad transitional zone uniting dissimilar bioceramic

composites. Journal American Ceramic Society 83:238-240.

Moradian-Oldak, J., Paine, M.L., Lei, Y.P., Fincham, A.G., Snead, M.L. (2000) Self-assembly

of recombinant engineered amelogenin proteins analyzed by dynamic light scattering

and atomic force microscopy. Journal Structural Biology 131:27-37.

Zhou, Y.L., Snead, M.L. (2000) Identification of CCAAT/enhancer-binding protein alpha as a

transactivator of the mouse amelogenin gene. Journal of Biological Chemistry.

275:22284-22292.

Zhou YL, Lei Y, and Snead ML. (2000) Mouse amelogenin gene expression Is mediated by

protein-protein interactions: functional antagonism between Msx2 and

CCAAT/Enhancer-binding protein a (C/EBP-alpha). Journal of Biological Chemistry

275:29066-29075.

Paine CT, Paine ML, Luo W, Okamoto CT, Lyngstadaas SP, Snead ML. (2000) A tuftelininteracting

protein (TIP39) localizes to the apical secretory pole of mouse ameloblasts.

Journal of Biological Chemistry. 275:22284-92.

1999

Dhamija, S., Liu, Y., Yamada, Y., Snead, M.L., Krebsbach, P.H. (1999) Cloning and

characterization of the murine ameloblastin promoter. Journal of Biological Chemistry

274:20738-20743.

Liu, Y-H., Tang, Z., Kundu, R.K., Wu, L., Luo, W., Zhu, D., Sangiorgi, F., Snead, M.L.,

Maxson, R.E., Jr. (1999) Msx2 gene dosage influences the number of proliferative

osteogenic cells in growth centers of the developing murine skull: A possible mechanism

of Msx2-mediated craniosynostosis . Developmental Biology 205:260-274.

1998

Nanci A, Zalzal S, Lavoie P, Kunikata M, Chen W, Krebsbach PH, Yamada Y, Hammarstrom

L, Simmer JP, Fincham AG, Snead ML, Smith CE. (1998) Comparative

immunochemical analyses of the developmental expression and distribution of

ameloblastin and amelogenin in rat incisors. Journal Histochemistry Cytochemistry.

46:911-34.

Paine, M.L., Krebsbach, P.H., Chen, L.S., Paine, C.T., Yamada, Y., Deutsch, D. and Snead,

M.L. (1998) Protein to protein interactions: Criteria defining the assembly of the enamel

organic matrix. (In Press) J Dental Research 77:496-503.

MALCOLM L. SNEAD DDS PHD 23

Jaskoll T, Luo W, Snead ML. (1998) Msx-2 expression and glucocorticoid-induced

overexpression in embryonic mouse submandibular glands. J Craniofacial Genetics

Developmental Biology. 18:79-87.

1997

Snead, M.L. (1997) Protein interactions defined by the yeast two-hybrid system. Ciba

Foundation Symposium No. 205 Dental Enamel, (Eds. D.J. Chadwick and G Cardew)

pp148-150

Paine, M.L. and Snead, M.L. (1997) Protein interactions during assembly of the enamel

organic extracellular matrix. Journal Bone and Mineral Research 12:221-227.

Liu, Yi H, Ma, L., Kundu, R., Ignelzi, M., Sangiorgi, F.S., Wu, L., Luo, W., Snead, M.L., and

Maxson (1997) Function of the Msx2 gene in the morphogenesis of the skull. Annals

New York Academy of Science

Fincham, A.G., Baehner, R., Chai, Y., Crowe, D.L., Fincham, C., Iskander, M., Landesman,

H.M., Lee, M., Luo, W., Paine, M., Pereira, L., Moradian-Oldak, J., Rosenblum, A.,

Snead, M.L., Thompson, P., Wuenschell, C., Zeichner-David, M., and Shuler, C.F.

(1997) Problem based learning at the University of Southern California school of

dentistry. Journal of Dental Education 61:417-425.

1996

Snead, M.L. (1996) Enamel biology logodaedaly: Getting to the root of the problem, or

“Who’s on first....” Journal of Bone Mineral Research 11: 899-904.

Snead, M.L. Paine, M.L., Chen, L.S., Yoshida, B., Luo, W., Zhou, D., Lei, Y.P., Liu, Y.H., and

Maxson, R.E. (1996) The Murine Amelogenin Promoter: Developmentally Regulated

Expression in Transgenic Animals. Connective Tissue Research 35(1-4):41-47.

Paine, M.L., Deutsch, D. and Snead, M.L. Carboxyl-region of tuftelin mediates selfassembly.

Connective Tissue Research 35(1-4)157-161.

1995

Liu, Y.H., Ma, L., Kundo, R., Luo, W., Snead, M.L., and Maxson, R. (1994) Defining the

minimal promoter of MSX2 required for apical ectodermal ridge expression by

transgenic animals. Mechanisms in Development 48:187-197.

MacDougall, M., Thiemann, F., Ta, H., Hsu, P., Chen, L.S., and Snead, M. L. (1995)

Temperature sensitive simian virus 40 large T antigen immortalization of murine

odontoblast cell cultures: Establishment of clonal odontoblast cell line. Connective

Tissue Research 33:97-103.

MALCOLM L. SNEAD DDS PHD 24

Liu, Y.H., Kundu, R., Wu, L., Luo, W., Ignelzi, M.A., Snead, M.L. and Maxson, R.E. (1995)

Premature suture closure and ectopic cranial bone in mice expressing MSX2 transgenes

in the developing skull. Proceedings of the National Academy of Science (USA)

92:6137-6141.

Ignelzi, M.A. Jr., Liu, Y.H., Maxson, R.E. Jr. and Snead, M.L. (1995) Genetically Engineered

Mice: Tools to understand craniofacial development. Critical Reviews Oral Biology and

Medicine 6:181-201.

Zeichner-David, M., Diekwisch, T., Fincham, A., Lau, E., MacDougall, M., Moradian-Oldak, J.,

Simmer, J., Snead, M.L. and Slavkin, H.C. (1995) Control of ameloblast differentiation.

Int. J. Dev. Biol. 39:69-92.

1994

Liu, Y.H., Ma, L., Wu, L.Y., Luo, W., Kundu, R., Sangiorgi, F., Snead, M.L., and Maxson, R.

Regulation of the Msx2 homeobox gene during mouse embryogenesis: A transgene with

439 bp of 5’ flanking sequence is expressed exclusively in the apical ectodermal ridge of

the developing limb. Mechanisms of Development 48:187-197 (1994)

Couwenhoven, R.I. and Snead, M.L. Instructive versus permissive influences in enamel

organ epithelial differentiation of the mouse mandibular first molar. Developmental

Biology 164:290-299 (1994)

Tong, H-S., Sakai, D.D., Sims, S.M., Dixon, S.J., Goldring, S.R., Yamin, M., Snead, M.L., and

Minkin, C. Murine osteoclasts and spleen cell polykaryons are distinguished by mRNA

phenotyping. Journal Bone Mineral Research 9:577-584 (1994).

Simmer, J.P., Lau, E.C., Hu, C.C., Aoba, T., Lacey, M., Nelson, D., Zeichner-David, M.,

Snead, M.L., Slavkin, H.C. and Fincham, A.G. Isolation and characterization of a mouse

amelogenin expressed in Escherichia coli. Calcif. Tissue Int. 54:312-319 (1994)

1993

Bell, J.R., Noveen, A., Liu, Y.H., Ma, L., Dobias, S., Kundu, R., Luo, W., Xia, Y., Lusis, A.J.,

Snead, M.L., and Maxson, R. (1993) Genomic structure, chromosomal location, and

evolution of the mouse HOX 8 gene. Genomics 16:123-131.

Jabs, E. W., Muller, U., Li, X., Ma, L., Luo, W., Haworth, I.S., Klisak, I., Sparkes, R.,

Warman, M.L., Mulliken, J.B., Snead, M.L. and Maxson R. (1993) A Mutation in the

homeodomain of the human MSX2 gene in a family affected with autosomal dominant

craniosynostosis. Cell 75:443-450.

Couwenhoven, R.I., Schwartz, S.A. and Snead, M.L. (1993) Arrest of amelogenin

transcription activation in bromodeoxyuridine treated developing mouse molars in vitro.

Journal Craniofacial Genetics and Developmental Biology, 13:259-269.

Shum, L., Sakakura, Y., Bringas,, P., Luo, W., Snead, M.L., Mayo, M., Crohin, C., Milar, S.,

Werb, Z., Buckley, S., Hall, F.L., Warburton, D., and Slavkin, H.C. (1993) EGF

MALCOLM L. SNEAD DDS PHD 25

abrogation-induced fusilli-form dysmorphogenesis of Meckel's cartilage during

embryonic mouse mandibular morphogenesis in vitro. Development 118:903-917.

1992

Gollard, R.P., Slavkin, H.C., and Snead, M.L. (1992) Polyoma virus induced murine

odontogenic tumors. Oral Surgery, Oral Medicine and Oral Pathology, 74:761-767.

Watson, J.M., Spencer, J.A., Graves, M. J.A., Snead, M.L. and Lau, E.C. (1992) Autosomal

localization for the amelogenin gene in monotremes and marsupials: Implications for

mammalian sex chromosome evolution. Genomics 14:785-789.

Lau, E.C., Simmer, J.P., Bringas, P., Hsu, D.D-J., Hu, C-C., Zeichner-David, M., Thiemann,

F., Snead, M.L., Slavkin, H.C., and Fincham, A.G. (1992) Alternative splicing of the

mouse amelogenin primary RNA transcript contributes to amelogenin heterogeneity.

Biochem. Biophy Res Comm 188: 1253-1260.

Chen, L.S., Couwenhoven, R.I., Hsu, D. D-J, Luo, W. and Snead, M.L. (1992) Maintenance

of amelogenin gene expression by transformed mouse enamel oral epithelial cells.

Archives Oral Biology 37:771-778.

Raaberg, L., Nexo, E., Buckley, S., Luo, W., Snead, M.L., and Warburton, D. (1992)

Epidermal growth factor: A novel autocrine mechanism in rat type II pneumocytes.

American Journal of Respiratory Cell and Molecular Biology 6:44-49.

Snead, M.L., Luo, W., Hsu, Dora, D-J, Melrose, R.J., Lau, E.C., and Stenman, G. (1992)

Human ameloblastoma tumors express the amelogenin gene. Oral Surgery, Oral

Medicine and Oral Pathology 74:64-72.

Jepsen, S., Schiltz, P., Strong, D.D., Scharla, S.H., Snead, M.L. and Finkelman, R.D. (1992)

Transforming growth factor beta 1 mRNA in neonatal ovine molars visualized by in situ

hybridization: Potential role for the stratum intermedium. Archives of Oral Biology

37:645-653.

1991

Fincham, A.G., Hu, Y., Lau, E.C., Slavkin, H.C. and Snead, M.L. (1991) Amelogenin postsecretory

processing during biomineralization in the postnatal mouse molar. Arch. oral

Biol. 36:305-317.

Chapman, V., Keitz, C., Stephenson, M., Lau, E.C., and Snead, M.L.: (1991) Linkage of

AMELOGENIN to the distal portion of the mouse X-chromosome. Genomics 10:23-28.

Luo, W., Slavkin, H.C. and Snead, M.L.: (1991) Cells from Hertwig's epithelial root sheath do

not transcribe amelogenin. J. Perio. Res. 26:42-47

Kidd, V.J., Luo, W., Xiang, J., Tu, F., Easton, J., McCune, S., Snead, M.L. (1991) Regulated

expression of a cell division control-related protein kinase during development. Cell

Growth & Differentiation. 2:85-93

1990

MALCOLM L. SNEAD DDS PHD 26

Lau, E.C., Slavkin, H.C. and Snead, M.L. (1990) Analysis of human enamel genes: Insights

into genetic disorders of enamel. The Cleft Palate Journal 27:121-130.

Fincham, A.G., Hu, Y., Lau, E., Pavlova, Z., Slavkin, H.C. and Snead, M.L. (1990) Isolation

and partial characterization of a human amelogenin from a single fetal dentition using

HPLC techniques. Calcif Tissue Int 47:105-111

Couwenhoven, R.I. Luo, W., and Snead, M.L. (1990) Co-localization of EGF transcripts and

peptides by combined immunohistochemistry and in situ hybridization. J. Histochem.

and Cytochem 38:1853-1857.

1989

Snead, M.L., Lau, E.C., Fincham, A.G., Zeichner-David, M., Davis, C. and Slavkin, H.C.

(1989). Of mice and men: Anatomy of the amelogenin gene. Connective Tissue

Research 22:101-109.

Zeichner-David, M., MacDougall, M., Davis, A., Vides, J., Snead, M.L., and Slavkin, H.C.

(1989). Enamelins and amelogenins share the same amino-terminal sequence.

Connective Tissue Research 22:123-129.

Snead, M.L., Luo, W., Oliver, P., Nakamura, M., Don-Wheeler, G., Bessem, C., Bell, G.I.,

Rall, L.B., and Slavkin, H.C. (1989) Localization of epidermal growth factor precursor in

tooth and lung during embryonic mouse development. Developmental Biology

134(2):420-429.

Amar, S., Luo, W., Snead, M.L., and Ruch, J.V. (1989) Amelogenin gene expression in

mouse incisor heterotypic recombinations. Differentiation 41:56-61.

Couwenhoven, R., Davis, C., and Snead, M.L. (1989) Mouse ameloblasts do not transcribe

the albumin gene. Calcified Tissue International 45:367-371.

Fincham, A.G., Hu, Y., Pavlova, Z., Slavkin, H.C., and Snead, M.L. (1989) Human

amelogenins: sequences of "TRAP" molecules. Calcified Tissue International 45:243-

250.

Fincham, A.G., Bessem, C., Bringas, P., Hu, Y., Snead, M.L., and Slavkin, H.C. (1989)

Amelogenesis in vitro: a model for studies of post-secretory processing during enamel

biomineralization. Differentiation 41:62-71.

Zeichner-David, M., MacDougall, M., Davis, A., Vides, J., Snead, M.L., and Slavkin, H.C.

(1989) Enamelins and amelogenins share the same amino-terminal sequence.

Connective Tissue Research 22:123-129.

Snead, M.L., Lau, E.C., Fincham, A.G., Zeichner-David, M., Davis, C. and Slavkin, H.C.

(1989) Of mice and men: Anatomy of the amelogenin gene. Connective Tissue

Research 22:101-109.

MALCOLM L. SNEAD DDS PHD 27

Luo, W., Roop, D.R., Lau, E.C., Melrose, R.J., Mostofi, R., Stenman, G., and Snead, M.L.

(1989) In situ hybridization Analysis of Keratin Gene Expression In Human

Ameloblastomas. J. Oral Pathology 17:534-540.

Slavkin, H.C., Bringas, P., Bessem, C., Santos, V., Nakamura, M., Hsu, M, Snead, M.L.,

Zeichner-David, M., and Fincham, A.G. (1989) Hertwig's epithelial root sheath

differentiation and initial cementum and bone formation during long-term organ culture of

mouse mandibular first molars using serum-less, chemically-defined medium. Journal of

Periodontal Research 23:28-40.

Slavkin, H.C., Bessem, C., Fincham, A.G., Bringas, P., Santos, V., Snead, M.L., and

Zeichner-David, M. (1989) Human and mouse cementum proteins immunologically

related to enamel proteins. Biochimica et Biophysica Acta 991:12-18.

Lau, E.C., Mohandas, T.K., Shapiro, L.J., Slavkin, H.C., and Snead, M.L. (1989) Human and

mouse amelogenin gene loci are on the sex chromosomes. Genomics 4:162-168.

1988

Snead, M.L., Luo, W., Lau, E.C., and Slavkin, H.C. (1988) Spatial- and temporal-restricted

pattern for amelogenin gene expression during mouse molar tooth organogenesis.

Development 104:77-85.

Slavkin, H.C., Bessem, C., Bringas, P., Zeichner-David, M., Nanci, A., and Snead, M.L.

(1988) Sequential expression and differential function of multiple enamel proteins during

fetal, neonatal and early postnatal stages of mouse molar organogenesis.

Differentiation 33:26-39.

Slavkin, H.C., MacDougall, M., Zeichner-David, M., Oliver, P.., Nakamura, M., and Snead,

M.L. (1988) Molecular determinants of cranial neural crest-derived odontogenic

ectomesenchyme during dentinogenesis. Amer J. Medical Genetics 4:7-22.

Zeichner-David, M., Vides, J., MacDougall, M., Fincham, A., Snead, M.L., Bessem, C., and

Slavkin, H.C. (1988) Biosynthesis and characterization of rabbit tooth enamel

extracellular matrix proteins. Biochem J. 251:631-641.

1987

Snead, M.L. and Lau, E. (1987) Examining the possible molecular origins for enamel protein

complexity. Advances In Dental Research 1:298-305.

Lau, E.C., Bessem, C.C., Slavkin, H.C., Zeichner-David, M., and Snead, M.L. (1987)

Amelogenin antigenic domain defined by clonal epitope selection. Calcif. Tissue Int.

40:231-237.

Zeichner-David, M., MacDougall, M., Vides, J., Snead, M. L., Slavkin, H.C., Turkel, S., and

Pavlova, Z. (1987) Immunochemical and biochemical studies of human enamel proteins

during neonatal development. Journal Dental Research 66:50-56.

MALCOLM L. SNEAD DDS PHD 28

1985 and Earlier

Snead, M.L., Lau, E.C., Zeichner-David, M., Fincham, A.G., Woo, S.L.C., and Slavkin, H.C.

(1985) DNA sequence for cloned cDNA for murine amelogenin reveal the amino acid

sequence for enamel-specific protein. Biochemical and Biophysical Research

Communications 129:812-818.

Slavkin, H.C., Snead, M.L., Zeichner-David, M., Jaskoll, T.F., and Smith, B.T. (1984)

Concepts of epithelial-mesenchymal interactions during development: tooth and lung

organogenesis. J. Cellular Biochemistry 26:117-125.

Snead, M.L., Bringas, P.,Jr., Bessem, C., and Slavkin, H.C. (1984) De novo gene induction

detected by amelogenin gene transcript analysis, in vivo. Developmental Biology

104:255-258.

Snead, M.L., Zeichner-David, M., Chandra, T., Robson, K.J.H., Woo S.L.C., and Slavkin,

H.C. (1983) Construction and identification of a mouse amelogenin cDNA clone. Proc.

Natl. Acad. Sci. (USA) 80:7254-7258.

Schwartz, S.A. and Snead, M.L. (1982) BrdU-DNA interactions during odontogenesis, in

vitro. Arch. Oral Biology 27:9-12.

Snead, M.L. (1981) Examinations and characterization of extracellular matrix components

requisite for odontogenesis, in vitro. Doctoral Dissertation, University of Chicago.

Snead, M.L. and Schwartz, S.A. (1980) Effect of 5 bromodeoxyuridine on extra-cellular matrix

during odontogenesis in vitro. Virchows Archiv 33:35-46.

Chapters in Books:

Snead, M.L., (2003) Enhancing the processes of discovery and innovation for optimal host

response at implant surfaces. (Eds, Jan Eirik Ellingsen and S Petter Lyngstadaas), CRC

Press.

Fincham, A.G., Moradian-Oldak, J., Paine, M.L., Snead, M.L. and Zeichner-David, M. (2000),

Enamel Biomineralization: The assembly and disassembly of the protein extracellular

organic matrix. In: Development, Function and Evolution of Teeth. (Eds. M.F. Teaford,

Moya Merideth Smith and Mark W.J. Ferguson) Cambridge University Press.

Snead, M.L. (1997) Application of the yeast two hybrid system to enamel protein assembly.

In: Dental Enamel (H.C. Slavkin and G.B. Winter) Ciba Foundation.

Snead, M.L. (1997) Analysis of the mouse amelogenin promoter. In: Dental Enamel (H.C.

Slavkin and G.B. Winter) Ciba Foundation.

Simmer, J.P. and Snead, M.L. (1995) Molecular biology of the amelogenin gene. In: Dental

Enamel: Formation to Destruction (C. Robinson, J. Kirkham and R. Shore, eds), CRC

Press.

Slavkin, M.L., Kresja, R.J., Fincham, A.G., Bringas, P., Santos, V., Sasano, Y., Snead, M.L.,

and Zeichner-David, M. (1991) Evolution of enamel proteins: A paradigm for

mechanisms of biomineralization. In: Mechanisms and Phylogeny of Mineralization in

Biological Systems (S. Suga and N. Nakahara, eds), Springer-Verlag,pp 383-389.

MALCOLM L. SNEAD DDS PHD 29

Snead, M.L., Lau, E.C, Fincham, A.G., Zeichner-David, M., and Slavkin, H.C. (1989)

Knowledge based molecular dissection of amelogenesis: The chromosomal location of

the amelogenin genes. In: Tooth Enamel V (R.W. Fearnhead, ed.), Florence Publishers,

Yokohama Japan, pp 261-269.

Snead, M.L., Lau, E.C., Fincham, A.G., Zeichner-David, M., Davis, C. and Slavkin, H.C.

(1989). Of mice and men: Anatomy of the amelogenin gene. In: The Chemistry and

Biology of Mineralized Tissue (M. Glimcher, ed.) Pergamommom Press, New York,

pp727-735

Zeichner-David, M., MacDougall, M., Davis, A., Vides, J., Snead, M.L., and Slavkin, H.C.

(1989). Enamelins and amelogenins share the same amino-terminal sequence. In: The

Chemistry and Biology of Mineralized Tissue (M. Glimcher, ed.) Pergamommom Press,

New York, pp 749-757.

Fincham, A.G., Hu, Y., Lau, E.C., Slavkin, H.C. and Snead, M.L. (1991) Amelogenin postsecretory

processing during biomineralization in the postnatal mouse molar. Arch. oral

Biol. 36:305-317.

Slavkin, H.C., Snead, M.L., Luo, W., Bringas, P., Kikunaga, S., Sasano, Y., Bessem, C.,

Mayo, M., MacDougall, M., Rall, L.B., Rappolee, D., and Werb, Z. (1989) Analysis of

embryonic cartilage and bone induction in a defined culture system. In: Bone Regulatory

Factors: Morphology, Biochemistry, Physiology and Pharmacology (A. Pecile and B.

deBernard, eds.) Plenum Publishing Co. Ltd.

Slavkin, H.C., Snead, M.L., Zeichner-David, M., MacDougall, M., Fincham, A., Lau, E.C., Luo,

W., Nakamura, M., Oliver, P., and Evans, J. (1987) Factors influencing expression of

dental ECM biomineralization. In: Cell and Molecular Biology of Hard Tissues (G. Rodan

and A. Caplan, eds.), John Wiley & Sons, Chichester, England. CIBA Foundation

Symposium 135.

Snead, M.L., Lau, E.C., Zeichner-David, M., Nanci, A., Bendayan, M., Bringas, P.,Jr.,

Bessem, C., and Slavkin, H.C. (1987) Relationship of the ameloblast biochemical

phenotype to morpho- and cyto-differentiation. In: Molecular Approaches To

Development Biology (E. Davidson and N. Firtel, eds.), Alan R. Liss, Inc., New York pp.

641-652.

Snead, M.L., Zeichner-David, M., Lau, E. DiLella, A., Woo, S.L.C., and Slavkin, H.C. (1985)

Enamel gene expression in selected vertebrates using nucleic acid hybridization probes.

In: Second International Conference on the Chemistry and Biology of Mineralized

Tissues (W.T.Butler, ed.), Elsevier, North Holland, New York pp. 270-273.

Zeichner-David, M., Vides, J., Snead, M.L., and Slavkin, H.C. (1985) Enamel protein

characterization by mRNA translation in a cell-free system. In: Second International

Conference on the Chemistry and Biology of Mineralized Tissues (W.T. Butler, ed.), pp

264-270.

Slavkin, H.C., Snead, M.L., Zeichner-David, M., Bringas, P., Jr., and Greenberg, G.L. (1984)

Amelogenin gene expression during epithelial-mesenchymal interactions. In: The Role

of Extracellular Matrix in Development (R.L. Trelstad, ed.), Alan R. Liss, Inc., New York

pp. 221-253.

Slavkin, H.C., Zeichner-David, M., Snead, M.L., Graham, E.E., Samuel, N., and Ferguson,

M.W.J. (1984) Amelogenesis in reptilia: evolutionary aspects of enamel gene products.

In: Structure, Function and Evolution of Reptiles (M.W.J. Ferguson, ed.), Academic

Press, Ltd., London, pp. 275-303.

Slavkin, H.C., Snead, M.L., Zeichner-David, M., Jaskoll, T.F., and Smith, B.T. (1984)

Concepts of epithelial-mesenchymal interactions during development: tooth and lung

MALCOLM L. SNEAD DDS PHD 30

organogenesis. In: Proceeding of the 1984 UCLA Symposia on Extracellular Matrix:

Structure and Function (A.H. Reddi, ed.), Alan Liss, New York pp. 275-303.

Slavkin, H.C., Zeichner-David, M., Snead, M.L., Bringas, P., Jr., Bessem, C., and Santos, V.

(1984) Epithelial-mesenchymal interactions and enamel gene inductions. In: Tooth

Enamel IV (R.W. Fearnhead and S. Suga, eds.), Elsevier/North Holland Publishers,

Amsterdam pp. 167-171.

Slavkin, H.C., Zeichner-David, M., Snead, M.L., Samuel, N., Bessem, C., and Bringas, P.

(1984) Genetic and phylogenetic aspects of enamel. In: Tooth Morphogenesis and

Differentiation (J.V. Ruch and A. Belcourt, eds.), INSERM, Paris, France 126:341-354.

Snead, M.L., Lidskey, A.S., DiLella, A.D., Zeichner-David, M., Woo S.L.C., and Slavkin, H.C.

(1984) Of mice and men: the cloning of enamel gene sequences. In: Tooth

Morphogenesis and Differentiation (J.V. Ruch, ed.), INSERM, Paris, France, pp. 363-

368.

Snead, M.L., Zeichner-David, M., Woo, S.L.C., and Slavkin, H.C. (1984) Construction and

identification of molecular clones to mouse enamel proteins: the anatomy and

physiology of the enamel genes. In: Tooth Enamel IV (R.W. Fearnhead and S. Suga,

eds.), Elsevier/North Holland Publishers, Amsterdam pp 172-176.

Zeichner-David, M., Vides, J., Snead, M.L., and Slavkin, H.C. (1984) Enamel gene

expression in selected vertebrates. In: Tooth Enamel IV (R.W. Fearnhead and S. Suga,

eds.), Elsevier North Holland Publishers, Amsterdam, pp 183-187.

Zeichner-David, M., Snead, M.L., and Slavkin, H.C. (1984) Genetic differences in enamel

gene products amongst mammalian species. In: Tooth Morphogenesis and

Differentiation (J.V. Ruch, ed.), INSERM, Paris, France 125:355-362.

ABSTRACTS

To preserve space no abstracts are listed.

OTHER

Snead, M.L. Developmental biology and pathobiology: Fusion through molecular biology.

Invited Guest Editorial, Journal of Dental Research (1989).

Snead, M.L. Enamel Biology Logodaedaly: Getting to the Root of the Problem, or "Who's on First..."

Invited Guest Editorial, Journal of Bone and Mineral Research (1996).

Selected Presentations

2015 Visiting Faculty Member

Xi'an Jiaotong University, Xi’an, China

2015 International Conference on the Characterization and Control of

Interfaces, Kurashiki, Japan

Plenary Address, Symposium on Powder Technology and Smart

Processing

2014 International Symposium on Biomimetic Materials Processing

Nagoya University, Nagoya, Japan

2013 University of Tsukuba, Institute of Materials Science, School of

Engineering, Tsukuba, Japan

2013 1st International Workshop on Solution Plasma and Molecular

Technologies (SPM1), Shibaura Institute of Technology, Tokyo,

Japan

2013 International Symposium on Biomimetic Materials Processing

Nagoya University, Nagoya, Japan

2013 Materials Research Society of Japan

International Union of Materials Research Societies

2012 Gordon Research Conference

Discussion Leader, Biomineralization

2012 Biomimetic Materials Processing Symposium (BMMP)

Nagoya University, Japan

2011 Gordon Research Conference

Discussion Leader, Biomineralization

2010 Gordon Research Conference

Discussion Leader, Biomineralization

2010 Scandanavian Society of Biomaterials, Norway

2010 Ecotopia, Nagoya, Japan

2006 National Science Foundation- MRSEC

Genetically Engineered Peptides in Engineering

2006 Gordon Research Conference

“Signal Transduction by Engineered Extracellular Matrices”

2005 8th International Conference on the Chemistry and Biology of

Mineralized Tissues.

2004 Gordon Research Conference

“Biomineralization”

2003 National Institute for Dental and Craniofacial Research

“Hierarchical scale contributes to the unique materials properties of

enamel”

1997 American Association for the Advancement of Science

"Revolution in Dental Education"

1997 VIth International Conference on Tooth Morphogenesis

1997 Gordon Research Conference

"Saliva and Salivary Glands."

Discussion Leader

1996 Gordon Conference

"Biomineralization"

1996 Ciba Foundation Symposium No 205

Dental Enamel

1995 Third Carolina Conference on Tooth Enamel

1995 American Association for Dental Research

“Homeobox Genes and Craniofacial Malformations”

1993 Gordon Conference, "Bones and Teeth"

1992 Fourth International Conference on the "Biology and Chemistry of

Mineralized Tissues".

MALCOLM L. SNEAD DDS PHD 14

1991 National Institute of Dental Research,

Workshop on "The Genetic Diseases of the Craniofacial Oral-Dental

Complex".

1990 University of California San Francisco

Graduate Program in Oral Biology

1990 West Coast Regional Developmental Biology Meeting

1989 International Association for Dental Research,

Symposia Speaker: "The Genomes of Bone and Teeth".

1989 The American Academy of Oral Pathology

1989 Tooth Enamel Symposium V: The Composition Properties and

Fundamental Structure of Tooth Enamel

1988 The Third International Conference

on the Chemistry and Biology of Mineralized Tissues

1987 The University of Chicago

The Zoller Lecture Series

1987 The Second Carolina Conference

on Tooth Enamel Formation

1987 The American Academy of Oral Pathology

1986 Gordon Conference, "Bones and Teeth"

1985 International Association for Dental Research, Symposia Speaker

1984 Tooth Enamel Symposium IV: The Composition Properties and

Fundamental Structure of Tooth Enamel

Selected Awards & Honors

AWARDS & FELLOWSHIPS

2010 Mellon Faculty Mentoring Award

University of Southern California

2007 Fulbright Senior Specialist Program

Developmental Biology and Paleoanthropology

University of Witwatersrand, South Africa

2001 Research in Oral Biology Award

International Association for Dental Research

2000 MERIT Award, National Institutes of Health

National Institute of Dental and Craniofacial Research,

1995 Fellow, American Association for the Advancement of Science

1985-1990 Research Career Development Award

United States Public Health Service

1988 Visiting Scientist Fellowship

Dana Farber Cancer Institute

Molecular Biology Computer Research Resource

1977-1979 Walter G. Zoller Fellow

The University of Chicago

Chicago, Illinois

1976-1977 Johnson and Johnson Fellow


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